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Liu X, et al.  (2007) Genetic and Comparative Transcriptome Analysis of Bromodomain Factor 1 in the Salt Stress Response of Saccharomyces cerevisiae. Curr Microbiol 54(4):325-30

Abstract: The Saccharomyces cerevisiae BDF1 gene, which encodes a bromodomain-containing transcription factor, was previously isolated by transposon mutugenesis in a screen for salt-sensitive mutants. However, the salt stress response mechanism regulated by bromodomain transcription factor 1 protein (Bdf1p) remains poorly understood. In this report, genetic analysis indicated that the salt sensitivity of the BDF1 deletion mutant was suppressed by increased gene dosage of its homologous gene BDF2. Furthermore, comparative transcriptome analysis revealed that the differences in transcriptional response between the wild type and the bdf1Delta mutant in the presence of salt stress (0.6 mol/L NaCl, 45 min) were mainly related to cell-wall biosynthesis, the mitochondria, and several unknown genes. Our results provided further information about the regulatory mechanism involved in the salt stress response and adds new insight for understanding the biological functional of bromdomain-containing proteins in cellular processes.

Status: Published Type: Journal Article PubMed ID: 17334841

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ACS2 ADH2 AGX1 ALD2 ALD3 APE3 ARI1 ARO10 ARO9 ATG33
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BAP2 BDF1 BDF2 BDH2 CAP1 CCW14 CRH1 CTR1 CTT1 CUP2
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SCP160 SDS24 SED1 SIM1 SIP18 SOD2 SOL4 SPG4 SPS100 SSA4
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