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Pothof J, et al.  (2003) Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Genes Dev 17(4):443-8

Abstract: An RNA interference (RNAi)-based genome-wide screen was performed to detect genes that contribute to genome stability in somatic cells of Caenorhabditis elegans. We identified 61 such genes; these also affect spontaneous mutagenesis in the germ line. Their sequence suggests a role in DNA repair and/or replication, in chromatin remodeling, or in cell cycle control; there are also many novel genes that are highly conserved from yeast to human. Because known mutator genes are causally involved in many hereditary and sporadic human cancers, it is likely that some of these new mutators are equally relevant in cancer etiology.

Status: Published Type: Journal Article PubMed ID: 12600937

Topics addressed in this paper

Number of different genes curated to this paper: 40

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Topics Genes linked to topics (#1 - 10 )
CDC1 CDC14 CDC53 CEF1 CTF18 CTI6 DCS2 GRC3 GTR1 HHT1
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Topics Genes linked to topics (#11 - 20 )
HHT2 HSL7 HST2 IRC20 JAC1 KSS1 MLH1 MSH2 MSH6 NCS6
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Topics Genes linked to topics (#21 - 30 )
PMS1 RAD17 RAD24 REV1 REX3 RFA2 RFC1 RFC5 RNR4 RPD3
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Topics Genes linked to topics (#31 - 40 )
SEN1 SET1 SET2 SGS1 SIN3 SKP1 SSN8 SWA2 UNG1 YKR018C
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