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Lockshon D, et al.  (2007) The sensitivity of yeast mutants to oleic Acid implicates the peroxisome and other processes in membrane function. Genetics 175(1):77-91

Abstract: The peroxisome, sole site of beta-oxidation in Saccharomyces cerevisiae, is known to be required for optimal growth in the presence of fatty acid. Screening the haploid yeast deletion collection identified ~130 genes, 23 encoding peroxisomal proteins, necessary for normal growth on oleic acid. Oleate slightly enhances growth of wild-type yeast and inhibits growth of all strains identified by the screen. Non-peroxisomal processes, among them chromatin modification by H2AZ, Pol II mediator function, and cell wall-associated activities, also prevent oleate toxicity. The most oleate-inhibited strains lack Sap190, a putative adaptor for the PP2A-type protein phosphatase Sit4 (that is also required for normal growth on oleate) and Ilm1, a protein of unknown function. Palmitoleate, the other main unsaturated fatty acid of Saccharomyces, fails to inhibit growth of the sap190Delta, sit4Delta and ilm1Deltastrains. Data is presented that suggests that oleate inhibition of the growth of a peroxisomal mutant is due to an increase in plasma membrane porosity. We propose that yeast deficient in peroxisomal and other functions are sensitive to oleate perhaps because of an inability to effectively control the fatty acid composition of membrane phospholipid.

Status: Published Type: Journal Article PubMed ID: 17151231

Topics addressed in this paper

Number of different genes curated to this paper: 138

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADO1 ADR1 AKR1 ARP6 ATG17 AVL9 BUD14 BUD22 BUD23 BUD31
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Topics Genes linked to topics (#11 - 20 )
CAR2 CBS1 CLA4 CTF8 DFG5 DIA2 DJP1 FEN1 FOX2 GAL11
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Topics Genes linked to topics (#21 - 30 )
GEP4 GGC1 GIM4 GIP2 GON7 GPT2 GSH1 HIR2 HOF1 HTZ1
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Topics Genes linked to topics (#31 - 40 )
IES2 ILM1 IRA2 IRC25 KCS1 KNS1 LEA1 LOA1 MDL2 MDM10
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Topics Genes linked to topics (#41 - 50 )
MDM20 MDM30 MED2 MET18 MFM1 MIS1 MOG1 MTC7 MUB1 NAT3
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Topics Genes linked to topics (#51 - 60 )
NBP2 NCS2 NDE1 NDI1 OAF1 OPT1 PAC10 PAT1 PDE2 PEX1
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Topics Genes linked to topics (#61 - 70 )
PEX10 PEX11 PEX12 PEX13 PEX14 PEX15 PEX17 PEX19 PEX22 PEX25
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Topics Genes linked to topics (#71 - 80 )
PEX3 PEX4 PEX5 PEX6 PEX7 PEX8 PGD1 PHB1 PHO88 PIP2
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Topics Genes linked to topics (#81 - 90 )
POT1 POX1 PRE9 PRS3 PTC1 RAM1 RBL2 RCF2 ROM1 RPA49
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Topics Genes linked to topics (#91 - 100 )
RPB4 RPL12B RPL19B RPL34B RPL8A RPN4 RPS11A RPS8A RRN10 RSC2
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Topics Genes linked to topics (#101 - 110 )
SAC1 SAM37 SAP190 SGO1 SHP1 SIN3 SIT4 SKN7 SOD1 SOH1
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Topics Genes linked to topics (#111 - 120 )
SPF1 SPO7 SPT21 SPT7 SRB2 SRB5 SRO7 SSZ1 STE11 SWR1
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Topics Genes linked to topics (#121 - 130 )
TIF3 TIM18 UBA4 UBR2 URM1 VPS4 VPS69 VPS71 WHI3 XRN1
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Topics Genes linked to topics (#131 - 138 )
YAF9 YFR035C YGL152C YJL211C YLL020C YNL120C YOL050C ZAP1
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