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Hwang GW, et al.  (2006) Identification of F-box proteins that are involved in resistance to methylmercury in Saccharomyces cerevisiae. FEBS Lett 580(30):6813-6818

Abstract: We searched for F-box proteins that might be related to the mechanism that protects Saccharomyces cerevisiae against the toxic effects of methylmercury. We found that overexpression of Hrt3 and of Ylr224w rendered yeast cells resistant to methylmercury. Yeast cells that overexpressed Hrt3 and Ylr224w were barely resistant to methylmercury in the presence of a proteasome inhibitor. Our results suggest the existence of some protein(s) that enhances the toxicity of methylmercury in yeast cells and, also, that overexpression of Hrt3 or Ylr224w can confer resistance to methylmercury by enhancing the polyubiquitination of this protein(s) and its degradation in proteasomes.

Status: Published Type: Journal Article PubMed ID: 17141224

Topics addressed in this paper

Number of different genes curated to this paper: 18

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Topics Genes linked to topics (#1 - 10 )
CDC4 COS111 CTF13 DAS1 DIA2 ELA1 GRR1 HRT3 MDM30 MET30
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Topics Genes linked to topics (#11 - 18 )
MFB1 RCY1 SKP1 SKP2 UFO1 YDR131C YDR306C YLR224W
Additional Literature blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball
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