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Freimoser FM, et al.  (2006) Systematic screening of polyphosphate (poly P) levels in yeast mutant cells reveals strong interdependence with primary metabolism. Genome Biol 7(11):R109

Abstract: ABSTRACT: BACKGROUND: Inorganic polyphosphate (poly P) occurs universally in all organisms from bacteria to man. It functions for example as a phosphate and energy store, and is involved in the activation and regulation of proteins. Despite its ubiquitous occurrence and important functions it is unclear how poly P is synthesized or how poly P metabolism is regulated in higher eukaryotes. This work describes a systematic analysis of poly P levels in yeast knockout strains mutated in almost every non-essential gene. RESULTS: After three consecutive screens, 255 genes (almost 4% of the yeast genome) were found to be involved in the maintenance of normal poly P content. Many of these genes encoded proteins functioning in the cytoplasm, the vacuole or in transport and transcription. Besides reduced poly P content, many strains also exhibited reduced total phosphate content, showed altered ATP and glycogen levels and were disturbed in the secretion of acid phosphatase. CONCLUSIONS: Cellular energy and phosphate homeostasis is suggested to result from the equilibrium between poly P, ATP and free phosphate within the cell. Poly P serves as a buffer for both ATP and free phosphate levels and is therefore the least essential and consequently most variable component in this network. However, strains with reduced poly P levels are not only affected in their ATP and phosphate content, but also in other components that depend on ATP or free phosphate content, such as glycogen or secreted phosphatase activity.

Status: Published Type: Journal Article PubMed ID: 17107617

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Number of different genes curated to this paper: 255

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ADE1 ADE3 AKR1 ALT2 APL5 APL6 APM3 APS3 ARO1 ARP5
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ATG12 ATG20 ATG34 ATP15 AVT6 BIL1 BLS1 BMH2 BUD23 BUR2
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CBC2 CCR4 CCZ1 CIK1 CKA2 CMC1 CNM67 COX14 CTK1 DDR2
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Topics Genes linked to topics (#31 - 40 )
DEF1 DGA1 DID4 DIN7 DPL1 ECM14 ECM18 ECM30 ECM33 EFG1
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EMC5 EMI5 ENV9 ERG24 ERG6 ERP4 ERV41 ERV46 FAB1 FKS1
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FRA1 FUN12 FYV1 GAT2 GCN5 GCR2 GEM1 GOS1 GPM3 GPR1
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Topics Genes linked to topics (#61 - 70 )
GRX3 GSP2 GUD1 HDA2 HIR2 HPR1 HRQ1 ICE2 ILM1 INM2
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IRC11 IRS4 KAP120 KRE1 KRE6 LOA1 LYP1 MAM1 MED2 MEK1
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MEP1 MET22 MET7 MFA1 MGR1 MGR3 MHR1 MIR1 MLP1 MON1
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Topics Genes linked to topics (#91 - 100 )
MRP51 MRPL27 MRPL33 MRPS16 MRS2 MSD1 MSH5 MSR1 NIT3 NOT5
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NRG1 NUP2 NUP60 OCA6 ODC1 OPT2 ORM2 PEP12 PEP4 PEP5
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PET117 PET122 PEX10 PEX17 PEX6 PFK1 PFK2 PHM8 PKR1 PLC1
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PRB1 PRK1 PTC6 PTP3 PUS7 PYK2 RAD61 RAM1 RAV1 RDI1
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RDR1 REG1 REV7 REX4 RIM1 RIM21 RPL14A RPL27A RPN10 RPO41
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RPS10A RPS11A RPS14A RSM19 RTC5 RXT3 SCT1 SDS24 SDS3 SEC66
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Topics Genes linked to topics (#151 - 160 )
SFG1 SFL1 SIR3 SKN7 SLP1 SMI1 SNQ2 SNT309 SNX4 SOD2
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SPE2 SPF1 SPH1 SPO19 SPT21 SRB8 SRL1 SSA4 SSN8 SSP2
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SUR2 SWF1 SWM1 TAF14 TAT2 TCO89 TEF4 TES1 THO2 THP1
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THP2 THR1 TIF3 TIM18 TOM5 TRF5 TRM3 TUF1 TVP15 UBR1
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UGA3 UME1 URE2 UTH1 VAC14 VAM10 VAM3 VMA10 VMA11 VMA13
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Topics Genes linked to topics (#201 - 210 )
VMA16 VMA22 VMA3 VMA5 VMA6 VMA8 VPH1 VPH2 VPS1 VPS24
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Topics Genes linked to topics (#211 - 220 )
VPS30 VPS33 VPS34 VPS5 VPS54 VPS73 VTC1 VTC2 VTC4 WHI5
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Topics Genes linked to topics (#221 - 230 )
YAT2 YBL012C YBL100C YDL162C YDR042C YDR114C YDR124W YDR161W YDR248C YDR249C
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Topics Genes linked to topics (#231 - 240 )
YDR278C YDR282C YER084W YFL042C YFR024C YGR151C YKL118W YKR047W YLR255C YLR358C
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Topics Genes linked to topics (#241 - 250 )
YNL198C YNL226W YOL019W YOL075C YOL079W YOL162W YOR240W YOR283W YOR296W YOR333C
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Topics Genes linked to topics (#251 - 255 )
YPL261C YPR099C YPT7 YTA7 YVC1
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