SGD Paper 
Gao L and Gross DS (2006) Using genomics and proteomics to investigate mechanisms of transcriptional silencing in Saccharomyces cerevisiae. Brief Funct Genomic Proteomic 5(4):280-8
Abstract: Silent chromatin in budding yeast is characterized by the presence of a specialized chromatin modification complex consisting of silent information regulator (Sir) proteins, closely packed pairs of nucleosomes, and hypoacetylated and hypomethylated histones. How this specialized chromatin is established, maintained and inherited has been extensively studied. Less investigated are the determinants that constrain its linear spread along the chromatin fibre and the manner by which it represses gene transcription. Here we review the essential features of SIR-mediated heterochromatin, and discuss genomic and proteomic approaches for discerning the composition of its boundaries and for elucidating the mechanisms by which it silences transcription.
| Status: Published | Type: Journal Article | PubMed ID: 17082210 |
Topics addressed in this paper
Number of different genes curated to this paper: 73
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| Topics | Genes linked to topics (#31 - 40 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ORC1 | POB3 | RAD6 | RAP1 | RPB10 | RPB11 | RPB2 | RPB3 | RPB4 | RPB5 | |
| Reviews |  | | | | | | | | | |
| Topics | Genes linked to topics (#41 - 50 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| RPB7 | RPB8 | RPB9 | RPC10 | RPO21 | RPO26 | SAS2 | SET1 | SGF11 | SGF29 | |
| Reviews | | | | | | | | | | |
| Topics | Genes linked to topics (#51 - 60 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SGF73 | SIR1 | SIR2 | SIR3 | SIR4 | SPT20 | SPT3 | SPT7 | SPT8 | SUS1 | |
| Reviews | | | | | | | | | | |
- To find other papers on a gene and topic, click on the colored ball in the appropriate box.
- displays other papers with information about that topic for that gene.
- displays other papers in SGD that are associated with that topic.
The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
- To go to the Locus page for a gene, click on the gene name.
| Topics | Genes linked to topics (#61 - 70 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SWC4 | SWR1 | TAF10 | TAF12 | TAF5 | TAF6 | TAF9 | TRA1 | YAF9 | YKU70 | |
| Reviews | | | | | | | | | | |
