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Parveen M, et al.  (2004) Response of Saccharomyces cerevisiae to a monoterpene: evaluation of antifungal potential by DNA microarray analysis. J Antimicrob Chemother 54(1):46-55

Abstract: Plant-derived essential oils with monoterpenoids have been used as antifungal drugs since ancient times, but the mode of action of these natural hydrocarbons at the molecular level is not understood. In order to understand the mechanisms of toxicity of alpha-terpinene (a cyclic monoterpene), a culture of Saccharomyces cerevisiae was exposed to 0.02% alpha-terpinene for 2 h and transcript profiles were obtained using yeast DNA arrays. These profiles, when compared with transcript profiles of untreated cultures, revealed that the expression of 793 genes was affected. For 435 genes, mRNA levels in treated cells compared with control cells differed by more than two-fold, whereas for 358 genes, it was <0.5-fold. Northern blots were performed for selected genes to verify the microarray results. Functional analysis of the up-regulated genes indicates that, similar to commonly used antifungal drugs, alpha-terpinene exposure affected genes involved in ergosterol biosynthesis and sterol uptake. In addition, transcriptional induction of genes related to lipid metabolism, cell wall structure and function, detoxification and cellular transport was observed in response to terpinene toxicity. Notably, the functions of 192 up-regulated genes are still unknown, but their characterization will probably shed light on the mechanisms of drug resistance and sensitivity. Taken together, this study showed that alpha-terpinene has strong antifungal activities and its modes of action resemble those of presently used antifungal drugs.

Status: Published Type: Journal Article PubMed ID: 15201226

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Number of different genes curated to this paper: 110

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AAD6 ADH5 ADH7 ADY2 AGA2 AMS1 ARG1 ARN2 ATF2 ATX1
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BCK1 BFR1 BSC1 BUD7 CAR2 CHO1 CHO2 CHS1 CIT2 CPA1
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Topics Genes linked to topics (#21 - 30 )
CRH1 CRS5 CSE2 CYB5 CYC3 CYS3 DAN1 ECM13 ECM4 ERG1
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Topics Genes linked to topics (#31 - 40 )
ERG24 ERG25 ERG28 ERG3 ERG5 ERG6 FAR3 FBP1 FMO1 FMS1
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Topics Genes linked to topics (#41 - 50 )
GDH3 GIT1 GLK1 GPM2 GSC2 GTT1 GUT1 HES1 HOP1 HOP2
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Topics Genes linked to topics (#51 - 60 )
HSP150 IDP2 IMP2' INO1 ITR1 JEN1 KNH1 KRE1 MAL13 MEK1
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Topics Genes linked to topics (#61 - 70 )
MET10 MET13 MET14 MET17 MET2 MET3 MET5 MET6 MET8 MMP1
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Topics Genes linked to topics (#71 - 80 )
MSL1 MSL5 MXR1 NCP1 NDT80 NRG1 OLE1 OPI3 PCK1 PET10
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Topics Genes linked to topics (#81 - 90 )
PHO84 PHO89 POT1 PPT2 PSD1 PUT3 PXA2 RAD50 RTA1 SAM2
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Topics Genes linked to topics (#91 - 100 )
SAM3 SCM4 SCW10 SHR5 SMP1 SNU23 SPO1 STR3 SUC2 SUL1
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Topics Genes linked to topics (#101 - 110 )
TDH3 TGL2 THI2 TSA2 UBC8 UPC2 YAT2 YDL041W YSR3 ZWF1
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