Cowen LE, et al. (2006) Genetic architecture of Hsp90-dependent drug resistance. Eukaryot Cell 5(12):2184-8
Abstract: Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic pathogen Candida albicans via calcineurin. Here, we explored effectors downstream of calcineurin regulating this Hsp90-dependent trait. Using S. cerevisiae erg3 mutants as a model, we determined that both Crz1 and Hph1 modulate azole resistance.
|Status: Published||Type: Journal Article||PubMed ID: 17056742|
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