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Ando A, et al.  (2007) Identification and classification of genes required for tolerance to freeze-thaw stress revealed by genome-wide screening of Saccharomyces cerevisiae deletion strains. FEMS Yeast Res 7(2):244-53

Abstract: Yeasts used in bread making are exposed to freeze-thaw stress during frozen-dough baking. To clarify the genes required for freeze-thaw tolerance, genome-wide screening was performed using the complete deletion strain collection of diploid Saccharomyces cerevisiae. The screening identified 58 gene deletions that conferred freeze-thaw sensitivity. These genes were then classified based on their cellular function and on the localization of their products. The results showed that the genes required for freeze-thaw tolerance were frequently involved in vacuole functions and cell wall biogenesis. The highest numbers of gene products were components of vacuolar H(+)-ATPase. Next, the cross-sensitivity of the freeze-thaw-sensitive mutants to oxidative stress and to cell wall stress was studied; both of these are environmental stresses closely related to freeze-thaw stress. The results showed that defects in the functions of vacuolar H(+)-ATPase conferred sensitivity to oxidative stress and to cell wall stress. In contrast, defects in gene products involved in cell wall assembly conferred sensitivity to cell wall stress but not to oxidative stress. Our results suggest the presence of at least two different mechanisms of freeze-thaw injury: oxidative stress generated during the freeze-thaw process, and defects in cell wall assembly.

Status: Published Type: Journal Article PubMed ID: 16989656

Topics addressed in this paper

Number of different genes curated to this paper: 59

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AIM4 AKR1 ANP1 BRE1 BUD19 CKB2 CTF4 DEG1 DIA2 EOS1
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Large-scale phenotype analysis yg ball
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Topics Genes linked to topics (#11 - 20 )
ERG24 FAB1 GAS1 GRR1 HMO1 LOC1 MNN10 MNN11 MRPL20 MRPL32
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Topics Genes linked to topics (#21 - 30 )
MTQ2 NSR1 PHO2 PMR1 PRO1 RPB4 RPB9 RPL27A RPL35A RPL39
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Topics Genes linked to topics (#31 - 40 )
RPS29B RSM19 SEC66 SHP1 SNF1 SNF5 SPT20 SPT21 SSE1 SWF1
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Topics Genes linked to topics (#41 - 50 )
VAC7 VMA1 VMA11 VMA13 VMA2 VMA21 VMA3 VMA4 VMA7 VMA8
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Topics Genes linked to topics (#51 - 59 )
VMA9 VPH1 VPH2 VPS45 YCL007C YDR161W YGL218W YGR160W YOR331C
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  • To go to the Locus page for a gene, click on the gene name.

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