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Yu L, et al.  (2006) A survey of essential gene function in the yeast cell division cycle. Mol Biol Cell 17(11):4736-47

Abstract: Monitoring Editor: Trisha Davis Mutations impacting specific stages of cell growth and division have provided a foundation for dissecting mechanisms that underlie cell cycle progression. We have undertaken an objective examination of the yeast cell cycle through flow cytometric analysis of DNA content in TetO7 promoter mutant strains representing 75% of all essential yeast genes. Over 65% of the strains displayed specific alterations in DNA content, suggesting that reduced function of an essential gene in most cases impairs progression through a specific stage of the cell cycle. Because of the large number of essential genes required for protein biosynthesis, G1 accumulation was the most common phenotype observed in our analysis. In contrast, relatively few mutants displayed S-phase delay, and most of these were defective in genes required for DNA replication or nucleotide metabolism. G2 accumulation appeared to arise from a variety of defects. In addition to providing a global view of the diversity of essential cellular processes that influence cell cycle progression, these data also provided predictions regarding the functions of individual genes: we identified four new genes involved in protein trafficking (NUS1, PHS1, PGA2, PGA3), and we found that CSE1 and SMC4 are important for DNA replication.

Status: Published Type: Journal Article PubMed ID: 16943325

Topics addressed in this paper

Number of different genes curated to this paper: 65

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ALA1 CDC1 CDC13 CDC14 CDC15 CDC16 CDC19 CDC20 CDC21 CDC23
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Large-scale phenotype analysis yg ball
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Topics Genes linked to topics (#11 - 20 )
CDC25 CDC27 CDC3 CDC34 CDC37 CDC4 CDC42 CDC43 CDC45 CDC48
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
CDC6 CDC8 CDC9 CSE1 DBF4 DFR1 DPB11 DPB2 DSN1 DUT1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
EMW1 ERG26 ESF2 FOL2 FRS1 GPA1 JIP5 MCM2 MCM4 MCM5
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Topics Genes linked to topics (#41 - 50 )
MCM7 MYO2 NUS1 PGA2 PGA3 PHS1 POL1 POL12 POL2 POL30
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Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#51 - 60 )
PRI2 PRT1 PSF1 PSF2 RAD3 RAT1 SEC27 SLD2 SLD5 SMC4
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Topics Genes linked to topics (#61 - 65 )
TIF6 TRM112 TRS120 YHR020W ZIM17
Additional Literature blue ball blue ball blue ball blue ball blue ball
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