Engelke DR and Hopper AK (2006) Modified view of tRNA: stability amid sequence diversity. Mol Cell 21(2):144-5
Abstract: In a recent issue of Molecular Cell, a report from the Phizicky lab challenges two commonly held notions regarding tRNAs: (1) tRNAs are stable molecules shielded from the machinery that cause other RNAs to have short half-lives, and (2) the many modifications found on tRNAs serve only subtle biological functions. Alexandrov et al. (2006) show that tRNA modifications can play an important role in tRNA stability, as without particular modifications, tRNA half-life can be reduced from hours to minutes by a new turnover pathway.
|Status: Published||Type: Comment | Journal Article | Review||PubMed ID: 16427003|
Topics addressed in this paper
Number of different genes curated to this paper: 21
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|Topics||Genes (#11 - 20 )|
|Topics||Genes (#21 )|