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Lew DJ and Burke DJ  (2003) The spindle assembly and spindle position checkpoints. Annu Rev Genet 37:251-82

Abstract: The mitotic spindle segregates chromosomes to opposite ends of the cell in preparation for cell division. Chromosome attachment to the spindle is monitored by the spindle assembly checkpoint, and at least in yeast cells, penetration of one spindle pole into the bud is monitored by the spindle position checkpoint. We review the historical origins of these checkpoints and recent progress in understanding their surveillance pathways. We also highlight fascinating but as yet unresolved questions, and examine crosstalk between the checkpoints.

Status: Published Type: Journal Article | Review PubMed ID: 14616062

Topics addressed in this paper

Number of different genes curated to this paper: 39

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AMA1 APC1 APC11 APC2 APC4 APC5 APC9 BFA1 BUB1 BUB2
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BUB3 CDC14 CDC15 CDC16 CDC20 CDC23 CDC26 CDC27 CDC5 CDH1
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DBF2 DOC1 IPL1 LTE1 MAD1 MAD2 MAD3 MND2 MOB1 MPS1
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Topics Genes linked to topics (#31 - 39 )
NUF2 NUP53 SPC24 SPC25 SWM1 TEM1 TID3 TUB1 TUB2
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