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Lew DJ and Burke DJ (2003) The spindle assembly and spindle position checkpoints. Annu Rev Genet 37:251-82
Abstract: The mitotic spindle segregates chromosomes to opposite ends of the cell in preparation for cell division. Chromosome attachment to the spindle is monitored by the spindle assembly checkpoint, and at least in yeast cells, penetration of one spindle pole into the bud is monitored by the spindle position checkpoint. We review the historical origins of these checkpoints and recent progress in understanding their surveillance pathways. We also highlight fascinating but as yet unresolved questions, and examine crosstalk between the checkpoints.
| Status: Published | Type: Journal Article | Review | PubMed ID: 14616062 |
Topics addressed in this paper
Number of different genes curated to this paper: 39
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