Dimster-Denk D, et al. (1999) Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reporter Matrix. J Lipid Res 40(5):850-60
Abstract: Gene expression profiling is rapidly becoming a mainstay of functional genomic studies. However, there have been relatively few studies of how the data from expression profiles integrate with more classic approaches to examine gene expression. This study used gene expression profiling of a portion of the genome of Saccharomyces cerevisiae to explore the impact of blocks in the isoprenoid biosynthetic pathway on the expression of genes and the regulation of this pathway. Approximately 50% of the genes whose expression was altered by blocks in isoprenoid biosynthesis were genes previously known to participate in the pathway. In contrast to this simple correspondence, the regulatory patterns revealed by different blocks, and in particular by antifungal azoles, was complex in a manner not anticipated by earlier studies.
| Status: Published | Type: Journal Article | PubMed ID: 10224154 |
Topics addressed in this paper
Number of different genes curated to this paper: 49
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| Topics | Topics not linked to Genes | Genes linked to topics (#1 - 10 ) | |||||||||
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| ARE1 | ARE2 | BEM1 | BET2 | BET4 | BTS1 | CAT5 | CDC43 | COQ1 | COQ2 | ||
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| Topics | Genes linked to topics (#11 - 20 ) | |||||||||
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| COQ3 | COQ6 | COX10 | ERG1 | ERG10 | ERG11 | ERG12 | ERG13 | ERG2 | ERG20 | |
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| Topics | Genes linked to topics (#21 - 30 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ERG24 | ERG3 | ERG4 | ERG5 | ERG6 | ERG7 | ERG8 | ERG9 | FAR1 | FAR3 | |
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| Regulation of | | | | | | | | | | |
- To find other papers on a gene and topic, click on the colored ball in the appropriate box.
- displays other papers with information about that topic for that gene.
- displays other papers in SGD that are associated with that topic.
The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
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| Topics | Genes linked to topics (#31 - 40 ) | |||||||||
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| FUS1 | HEM14 | HMG1 | HMG2 | IDI1 | KAR4 | MFA1 | MFA2 | MOD5 | MVD1 | |
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| Topics | Genes linked to topics (#41 - 49 ) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| RAM1 | RAM2 | RAS1 | RAS2 | RCE1 | STE14 | STE18 | STE2 | STE24 | |
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