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Raveendranathan M, et al.  (2006) Genome-wide replication profiles of S-phase checkpoint mutants reveal fragile sites in yeast. EMBO J 25(15):3627-39

Abstract: The S-phase checkpoint kinases Mec1 and Rad53 in the budding yeast, Saccharomyces cerevisiae, are activated in response to replication stress that induces replication fork arrest. In the absence of a functional S-phase checkpoint, stalled replication forks collapse and give rise to chromosome breakage. In an attempt to better understand replication dynamics in S-phase checkpoint mutants, we developed a replication origin array for budding yeast that contains 424 of 432 previously identified potential origin regions. As expected, mec1-1 and rad53-1 mutants failed to inhibit late origin activation. Surprisingly however, 17 early-firing regions were not replicated efficiently in these mutants. This was not due to a lack of initiation, but rather to problems during elongation, as replication forks arrested in close proximity to these origins, resulting in the accumulation of small replication intermediates and eventual replication fork collapse. Importantly, these regions were not only prone to chromosome breakage in the presence of exogenous stress but also in its absence, similar to fragile sites in the human genome.

Status: Published Type: Journal Article PubMed ID: 16888628

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ARS1102 ARS1104 ARS1115 ARS1202 ARS1207 ARS1214 ARS1219 ARS1221 ARS1228 ARS1230
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Topics Genes linked to topics (#11 - 20 )
ARS1304 ARS1305 ARS1317 ARS1319 ARS1321 ARS1322 ARS1331 ARS1333 ARS1335 ARS1407
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Topics Genes linked to topics (#21 - 30 )
ARS1409 ARS1410 ARS1416 ARS1423 ARS1425 ARS1426 ARS1510 ARS1512 ARS1518 ARS1603
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Topics Genes linked to topics (#31 - 40 )
ARS1608 ARS1611 ARS1612 ARS1617 ARS1620 ARS1629 ARS1632 ARS208 ARS212 ARS213
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Topics Genes linked to topics (#41 - 50 )
ARS221 ARS305 ARS310 ARS315 ARS411 ARS412 ARS415 ARS420 ARS427 ARS436
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Topics Genes linked to topics (#51 - 60 )
ARS439 ARS442 ARS606 ARS709 ARS712 ARS715 ARS718 ARS723 ARS724 ARS728
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Topics Genes linked to topics (#61 - 70 )
ARS735 ARS736 ARS801 ARS806 ARS810 ARS811 ARS814 ARS815 ARS902 ARS904
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Topics Genes linked to topics (#71 - 77 )
ARS909 ARS910 ARS915 ARS918 ARS921 MEC1 RAD53
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