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Nieduszynski CA, et al.  (2006) Genome-wide identification of replication origins in yeast by comparative genomics. Genes Dev 20(14):1874-9

Abstract: We discovered that sequences essential for replication origin function are frequently conserved in sensu stricto Saccharomyces species. Here we use analysis of phylogenetic conservation to identify replication origin sequences throughout the Saccharomyces cerevisiae genome at base pair resolution. Origin activity was confirmed for each of 228 predicted sites-representing 86% of apparent origin regions. This is the first study to determine the genome-wide location of replication origins at a resolution sufficient to identify the sequence elements bound by replication proteins. Our results demonstrate that phylogenetic conservation can be used to identify the origin sequences responsible for replicating a eukaryotic genome.

Status: Published Type: Journal Article PubMed ID: 16847347

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Topics Genes linked to topics (#91 - 100 )
ARS1607 ARS1614 ARS1618 ARS1619 ARS1621 ARS1622 ARS1623 ARS1624 ARS1625 ARS1626
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Topics Genes linked to topics (#111 - 120 )
ARS211 ARS214 ARS215 ARS216 ARS220 ARS222 ARS224 ARS225 ARS228 ARS230
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Topics Genes linked to topics (#121 - 130 )
ARS231 ARS313 ARS314 ARS315 ARS316 ARS403 ARS405 ARS406 ARS409 ARS410
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Topics Genes linked to topics (#131 - 140 )
ARS413 ARS414 ARS417 ARS418 ARS419 ARS421 ARS422 ARS423 ARS425 ARS428
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ARS429 ARS430 ARS431 ARS432 ARS433 ARS434 ARS435 ARS440 ARS443 ARS446
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ARS450 ARS451 ARS452 ARS453 ARS507 ARS508 ARS510 ARS511 ARS512 ARS514
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ARS517 ARS518 ARS522 ARS702 ARS704 ARS707 ARS710 ARS714 ARS716 ARS717
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ARS734 ARS737 ARS802 ARS805 ARS807 ARS809 ARS813 ARS818 ARS820 ARS822
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Topics Genes linked to topics (#191 - 200 )
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