Juneau K, et al. (2006) Introns regulate RNA and protein abundance in yeast. Genetics 174(1):511-8
Abstract: The purpose of introns in the architecturally simple genome of Saccharomyces cerevisiae is not well understood. To assay the functional relevance of introns, a series of computational analyses and several detailed deletion studies were completed on the intronic genes of Saccharomyces cerevisiae. Mining existing data from genome-wide studies on yeast, it was discovered that intron containing genes produce more RNA, more protein and are more likely to be haploinsufficient than non-intronic genes. These observations for all intronic genes held true for distinct subsets of genes including ribosomal, non-ribosomal, duplicated and non-duplicated. Corroborating the result of computational analyses, deletion of introns from three essential genes decreased cellular RNA levels and caused measurable growth defects. These data provide evidence that introns improve transcriptional and translational yield and are required for competitive growth of yeast.
|Status: Published||Type: Journal Article||PubMed ID: 16816425|
Topics addressed in this paper
Number of different genes curated to this paper: 3
- To find other papers on a gene and topic, click on the colored ball in the appropriate box.
- displays other papers with information about that topic for that gene.
- displays other papers in SGD that are associated with that topic.
The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
- To go to the Locus page for a gene, click on the gene name.