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Tzagoloff A, et al.  (1975) Assembly of the mitochondrial membrane system. Cytoplasmic mutants of Saccharomyces cerevisiae with lesions in enzymes of the respiratory chain and in the mitochondrial ATPase. J Biol Chem 250(20):8236-42

Abstract: Mutants of Saccharomyces cervisiae with defects in enzymes of the electron transfer chain and in the rutamycin-sensitive ATPase have been isolated. Some of the mutants are specifically affected in either cytochrome oxidase, coenzyme QH2-cytochrome c reductase or ATPase. Other strains are deficient in both cytochrome oxidase and coenzyme QH2-cytochrome c reductase but still have rutamycin-sensitive ATPase. All the mutants reported in this study fail to be complemented by a rho0 tester derived from a respiratory competent strain. The meiotic spore progeny obtained by mating the mutants to a respiratory competent haploid yeast, when scored for growth on glycerol, show a non-Mendelian segregation of the phenotype. These two genetic tests indicate the mutations to be cytoplasmically inherited.FAU - Tzagoloff, .

Status: Published Type: Journal Article PubMed ID: 171256

Topics addressed in this paper

Number of different genes curated to this paper: 22

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Topics Genes linked to topics (#1 - 10 )
COB COR1 COX1 COX12 COX13 COX2 COX3 COX4 COX5A COX5B
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Topics Genes linked to topics (#11 - 20 )
COX6 COX7 COX8 COX9 CYT1 QCR10 QCR2 QCR6 QCR7 QCR8
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Topics Genes linked to topics (#21 - 22 )
QCR9 RIP1
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