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Rempola B, et al.  (2006) Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing. Biochem Biophys Res Commun 346(2):546-54

Abstract: The uncharacterized Saccharomyces cerevisiae proteins Fcf1 and Fcf2, encoded by the ORFs YDR339c and YLR051c, respectively, were identified in a tandem affinity purification experiment of the known 40S factor Faf1p. Most of the proteins associated with TAP-Faf1p are trans-acting factors involved in pre-rRNA processing and 40S subunit biogenesis, in agreement with the previously observed role of Faf1p in 18S rRNA synthesis. Fcf1p and Fcf2p are both essential and localize to the nucleolus. Depletion of Fcf1p and Fcf2p leads to a decrease in synthesis of the 18S rRNA, resulting in a deficit in 40S ribosomal subunits. Northern analysis indicates inefficient processing of pre-rRNA at the A(0), A(1), and A(2) cleavage sites.

Status: Published Type: Journal Article PubMed ID: 16762320

Topics addressed in this paper

Number of different genes curated to this paper: 45

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Topics Genes linked to topics (#1 - 10 )
BFR2 BMS1 BUD21 DIP2 ECM16 EMG1 FAF1 FCF1 FCF2 IMP3
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball
DNA/RNA Sequence Features blue ball
Function/Process blue ball blue ball
Fungal Related Genes/Proteins blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball
Primary Literature blue ball blue ball
Protein Sequence Features blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball
Strains/Constructs blue ball blue ball blue ball
Transcription blue ball

Topics Genes linked to topics (#11 - 20 )
IMP4 KRE33 KRR1 LCP5 MPP10 NAN1 NOC4 NOP1 NOP14 PNO1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
PWP2 RCL1 RPS13 RPS1A RPS4A RPS5 RPS6B RPS7A RRP9 SAS10
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
SOF1 UTP10 UTP11 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#41 - 45 )
UTP4 UTP5 UTP7 UTP8 UTP9
Additional Literature blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball

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