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Lawler JF Jr, et al.  (2002) A nucleocapsid functionality contained within the amino terminus of the Ty1 protease that is distinct and separable from proteolytic activity. J Virol 76(1):346-54

Abstract: Ty1 is the most successful of the five endogenous yeast retrotransposons. The life cycle of Ty1 dictates that a number of nucleocapsid (NC)-facilitated events occur although the protein(s) responsible for these events has not been identified. The positioning of the NC peptide is conserved at the carboxy terminus of the Gag protein among most long terminal repeat (LTR)-containing retroelements. An analogous region of Ty1 that simultaneously encodes part of Gag, protease (PR), and the C-terminal p4 peptide was mutagenized. Some of these mutations result in smaller-than-normal virus-like particles (VLPs). The mutants were also found to impair an NC-like functionality contained within the amino terminus of the protease that is distinct and separable from its proteolytic activity. Remarkably, these mutants have distinct defects in reverse transcription.

Status: Published Type: Journal Article PubMed ID: 11739699

Topics addressed in this paper

Number of different genes curated to this paper: 57

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Topics Genes linked to topics (#1 - 10 )
YBL005W-B YBLWTy1-1 YBR012W-B YBRWTy1-2 YDR098C-B YDR210C-D YDR316W-B YDR365W-B YDRCTy1-1 YDRCTy1-2
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Topics Genes linked to topics (#11 - 20 )
YDRWTy1-4 YDRWTy1-5 YER138C YER160C YERCTy1-1 YERCTy1-2 YGR027W-B YGR038C-B YGR161C-D YGRCTy1-2
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Topics Genes linked to topics (#21 - 30 )
YGRCTy1-3 YGRWTy1-1 YHR214C-B YHRCTy1-1 YJR027W YJR029W YJRWTy1-1 YJRWTy1-2 YLR157C-B YLR256W-A
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Topics Genes linked to topics (#31 - 40 )
YLRCTy1-1 YLRWTy1-2 YLRWTy1-3 YML039W YML045W YMLWTy1-1 YMLWTy1-2 YMR045C YMR050C YMRCTy1-3
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Topics Genes linked to topics (#41 - 50 )
YMRCTy1-4 YNL054W-B YNL284C-B YNLCTy1-1 YNLWTy1-2 YOL103W-B YOLWTy1-1 YOR142W-B YORWTy1-2 YPL257W-B
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Topics Genes linked to topics (#51 - 57 )
YPLWTy1-1 YPR137C-B YPR158C-D YPR158W-B YPRCTy1-2 YPRCTy1-4 YPRWTy1-3
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