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Workman CT, et al.  (2006) A systems approach to mapping DNA damage response pathways. Science 312(5776):1054-9

Abstract: Failure of cells to respond to DNA damage is a primary event associated with mutagenesis and environmental toxicity. To map the transcriptional network controlling the damage response, we measured genomewide binding locations for 30 damage-related transcription factors (TFs) after exposure of yeast to methyl-methanesulfonate (MMS). The resulting 5272 TF-target interactions revealed extensive changes in the pattern of promoter binding and identified damage-specific binding motifs. As systematic functional validation, we identified interactions for which the target changed expression in wild-type cells in response to MMS but was nonresponsive in cells lacking the TF. Validated interactions were assembled into causal pathway models that provide global hypotheses of how signaling, transcription, and phenotype are integrated after damage.

Status: Published Type: Journal Article PubMed ID: 16709784

Topics addressed in this paper

Number of different genes curated to this paper: 30

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ACE2 ADR1 ASH1 CAD1 CIN5 DAL81 DIG1 ECM22 FKH2 FZF1
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Computational analysis yg ball
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Topics Genes linked to topics (#11 - 20 )
GCN4 HSF1 INO4 IXR1 MCM1 MSN4 NDD1 PDR1 RFX1 RIM101
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Regulatory Role blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
RPN4 RTG3 SKO1 SOK2 SWI4 SWI5 SWI6 UGA3 YAP1 YAP5
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genomic co-immunoprecipitation study blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genomic expression study blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Other Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

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