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Snoek IS and Steensma HY  (2006) Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome. FEMS Yeast Res 6(3):393-403

Abstract: Although some yeast species, e.g. Saccharomyces cerevisiae, can grow under anaerobic conditions, Kluyveromyces lactis cannot. In a systematic study, we have determined which S. cerevisiae genes are required for growth without oxygen. This has been done by using the yeast deletion library. Both aerobically essential and nonessential genes have been tested for their necessity for anaerobic growth. Upon comparison of the K. lactis genome with the genes found to be anaerobically important in S. cerevisiae, which yielded 20 genes that are missing in K. lactis, we hypothesize that lack of import of sterols might be one of the more important reasons that K. lactis cannot grow in the absence of oxygen.

Status: Published Type: Journal Article PubMed ID: 16630279

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Number of different genes curated to this paper: 89

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ACP1 ARB1 ARG82 ARH1 ARV1 ATM1 BTS1 BUR6 CAB2 CAX4
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Topics Genes linked to topics (#11 - 20 )
CDC40 CNM67 CTF4 DBP7 DRS2 ERG1 ERG26 ERG27 ERG7 ERG9
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Topics Genes linked to topics (#21 - 30 )
ERV1 FAS2 FHL1 FOL3 FZO1 GLE2 GPA1 GUP1 HFI1 HPR1
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Topics Genes linked to topics (#31 - 40 )
HSP60 HYP2 IES2 INO80 JAC1 KAE1 LCD1 LSM5 LTO1 MET4
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Topics Genes linked to topics (#41 - 50 )
MIA40 MRPL10 NPT1 NSE5 OLE1 PET9 PGD1 POP7 PRI1 PXR1
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Topics Genes linked to topics (#51 - 60 )
RHO3 RIM2 RIM8 RNT1 RPL32 RPM2 RPN9 RRP17 SAH1 SAM35
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Topics Genes linked to topics (#61 - 70 )
SAM50 SDO1 SEC3 SEC5 SHR3 SIN4 SIS1 SNF1 SPT20 SUA5
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Topics Genes linked to topics (#71 - 80 )
TOM20 TRM112 TRM7 TRR1 ULP1 UTR5 VPS65 YAE1 YBR190W YDR149C
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Topics Genes linked to topics (#81 - 89 )
YFH1 YGL046W YGL069C YLR101C YLR140W YMR134W YNL171C YOR218C YPI1
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