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Gatbonton T, et al.  (2006) Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast. PLoS Genet 2(3):e35

Abstract: Telomere length-variation in deletion strains of Saccharomyces cerevisiae was used to identify genes and pathways that regulate telomere length. We found 72 genes that when deleted confer short telomeres, and 80 genes that confer long telomeres relative to those of wild-type yeast. Among identified genes, 88 have not been previously implicated in telomere length control. Genes that regulate telomere length span a variety of functions that can be broadly separated into telomerase-dependent and telomerase-independent pathways. We also found 39 genes that have an important role in telomere maintenance or cell proliferation in the absence of telomerase, including genes that participate in deoxyribonucleotide biosynthesis, sister chromatid cohesion, and vacuolar protein sorting. Given the large number of loci identified, we investigated telomere lengths in 13 wild yeast strains and found substantial natural variation in telomere length among the isolates. Furthermore, we crossed a wild isolate to a laboratory strain and analyzed telomere length in 122 progeny. Genome-wide linkage analysis among these segregants revealed two loci that account for 30%-35% of telomere length-variation between the strains. These findings support a general model of telomere length-variation in outbred populations that results from polymorphisms at a large number of loci. Furthermore, our results laid the foundation for studying genetic determinants of telomere length-variation and their roles in human disease.

Status: Published Type: Journal Article PubMed ID: 16552446

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AHC2 APN1 ARD1 ARF1 ATC1 ATG17 BRE1 BUD21 CBC2 CDC73
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CHO2 CTF8 CYC8 DCC1 DIG1 DOA4 DUN1 EBS1 ELG1 ERG2
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Topics Genes linked to topics (#21 - 30 )
EST1 EST2 EST3 FYV4 FYV6 GAL11 GLO4 GTR2 HCR1 HFI1
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Topics Genes linked to topics (#31 - 40 )
HIT1 HMO1 HTL1 IMG2 KRE28 LDB7 LEA1 LEO1 LSM7 MAK10
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Topics Genes linked to topics (#41 - 50 )
MAK3 MAK31 MDM10 MED1 MET7 MOT2 MOT3 MRC1 MRM2 MRPL44
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Topics Genes linked to topics (#51 - 60 )
NAM7 NAT3 NMD2 NPL6 NSR1 PAF1 PFD1 PGD1 PHO88 PIF1
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Topics Genes linked to topics (#61 - 70 )
POL32 PRO1 PRS3 PRS5 RAD27 RAD5 RAD50 RAD6 REF2 RFM1
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RIF1 RIF2 RNR1 RPA14 RPB4 RPL13B RPL34B RPS11B RPS16A RPS16B
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Topics Genes linked to topics (#81 - 90 )
RPS17B RPS18A RPS19A RPS21A RPS22A RPS23A RPS23B RPS27B RPS28B RPS30B
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Topics Genes linked to topics (#91 - 100 )
RPS4A RRP8 RSA1 RTF1 SEM1 SHP1 SIR4 SIW14 SLA2 SLI15
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Topics Genes linked to topics (#101 - 110 )
SLX8 SNC2 SNF8 SOL2 SPT21 SRB2 SRB5 SRB8 SSH1 SSN2
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Topics Genes linked to topics (#111 - 120 )
SSN3 STO1 STP22 SUM1 SWA2 TEL1 TIF1 TLC1 UPF3 VPS15
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Topics Genes linked to topics (#121 - 130 )
VPS28 VPS34 VPS54 WHI2 XRN1 XRS2 YBR284W YGR160W YHL012W YKU70
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Topics Genes linked to topics (#131 - 133 )
YKU80 YPT7 ZEO1
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