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Lebaron S, et al.  (2005) The splicing ATPase prp43p is a component of multiple preribosomal particles. Mol Cell Biol 25(21):9269-82

Abstract: Prp43p is a putative helicase of the DEAH family which is required for the release of the lariat intron from the spliceosome. Prp43p could also play a role in ribosome synthesis, since it accumulates in the nucleolus. Consistent with this hypothesis, we find that depletion of Prp43p leads to accumulation of 35S pre-rRNA and strongly reduces levels of all downstream pre-rRNA processing intermediates. As a result, the steady-state levels of mature rRNAs are greatly diminished following Prp43p depletion. We present data arguing that such effects are unlikely to be solely due to splicing defects. Moreover, we demonstrate by a combination of a comprehensive two-hybrid screen, tandem-affinity purification followed by mass spectrometry, and Northern analyses that Prp43p is associated with 90S, pre-60S, and pre-40S ribosomal particles. Prp43p seems preferentially associated with Pfa1p, a novel specific component of pre-40S ribosomal particles. In addition, Prp43p interacts with components of the RNA polymerase I (Pol I) transcription machinery and with mature 18S and 25S rRNAs. Hence, Prp43p might be delivered to nascent 90S ribosomal particles during pre-rRNA transcription and remain associated with preribosomal particles until their final maturation steps in the cytoplasm. Our data also suggest that the ATPase activity of Prp43p is required for early steps of pre-rRNA processing and normal accumulation of mature rRNAs.

Status: Published Type: Journal Article PubMed ID: 16227579

Topics addressed in this paper

Number of different genes curated to this paper: 100

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ALB1 ARB1 ARP9 ARX1 BMS1 BRR2 BRX1 BUD31 CBF5 CIC1
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CLF1 CWC2 CWC23 DBP10 DBP2 EBP2 ERB1 FPR3 FPR4 GAR1
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GSP1 GSP2 HAS1 HHF1 HHF2 HTA1 HTA2 HTB1 HTB2 HTZ1
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Topics Genes linked to topics (#31 - 40 )
KRE33 KRR1 LEA1 LSG1 LSM12 MAK21 MRT4 NHP2 NOG1 NOG2
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NOP1 NOP12 NOP13 NOP53 NOP56 NOP58 NSA2 NSR1 NTC20 NTR2
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Topics Genes linked to topics (#51 - 60 )
NUG1 PRP43 PRP45 PRP46 PRP8 PXR1 RIO1 RPA135 RPA190 RPA34
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Topics Genes linked to topics (#61 - 70 )
RPA49 RPC19 RPF1 RRP1 RRP12 RRP14 RRP5 RSA4 SMB1 SMD2
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Topics Genes linked to topics (#71 - 80 )
SMD3 SNF2 SNF5 SNU114 SNU13 SPB1 SPP382 SPT2 SPT7 SQS1
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Topics Genes linked to topics (#81 - 90 )
SRP1 SRP40 SSF2 SSL1 SWI1 SWI3 SXM1 SYF2 TAF6 TMA16
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Topics Genes linked to topics (#91 - 100 )
URB1 UTP10 UTP14 UTP15 UTP20 UTP22 UTP9 XRN1 YCR016W YGR130C
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