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Barz T, et al.  (2003) Perturbation of protein kinase CK2 uncouples executive part of phosphate maintenance pathway from cyclin-CDK control. FEBS Lett 537(1-3):210-4

Abstract: The budding yeast Saccharomyces cerevisiae encounters phosphate starvation by the transcription-regulated PHO pathway. We find that genetic perturbation of protein kinase CK2, a conserved tetrameric Ser/Thr phosphotransferase with links to cell cycle and transcription, affects expression of PHO pathway genes in a subunit- and isoform-specific manner. Remarkably, the genes encoding phosphate supplying phosphatases and transporters are significantly repressed, while the genes encoding components of the central pathway regulator complex, a cyclin-dependent kinase (CDK), a cyclin, and a CDK inhibitor, remain unaltered. Thus, perturbation of CK2 uncouples the executive part of the PHO pathway from its cyclin-CDK control complex.

Status: Published Type: Journal Article PubMed ID: 12606059

Topics addressed in this paper

Number of different genes curated to this paper: 19

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Topics Genes linked to topics (#1 - 10 )
CKA1 CKA2 CKB1 CKB2 GDE1 HOR2 PHM6 PHM7 PHO11 PHO12
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Topics Genes linked to topics (#11 - 19 )
PHO3 PHO4 PHO5 PHO8 PHO84 PHO89 SPL2 VTC3 VTC4
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Protein Processing/Modification/Regulation blue ball
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