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Pan X, et al.  (2006) A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell 124(5):1069-81

Abstract: A network governing DNA integrity was identified in yeast by a global genetic analysis of synthetic fitness or lethality defect (SFL) interactions. Within this network, 16 functional modules or minipathways were defined based on patterns of global SFL interactions. Modules or genes involved in DNA replication, DNA-replication checkpoint (DRC) signaling, and oxidative stress response were identified as the major guardians against lethal spontaneous DNA damage, efficient repair of which requires the functions of the DNA-damage checkpoint signaling and multiple DNA-repair pathways. This genome-wide genetic interaction network also identified novel components (DIA2, NPT1, HST3, HST4, and the CSM1 module) that potentially contribute to mitotic DNA replication and genomic stability and revealed novel functions of well-studied genes (the CTF18 module) in DRC signaling. This network will guide more detailed characterization of mechanisms governing DNA integrity in yeast and other organisms.

Status: Published Type: Journal Article PubMed ID: 16487579

Topics addressed in this paper

Number of different genes curated to this paper: 38

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
BRE1 CCS1 CSM1 CSM3 CTF18 CTF4 CTF8 DCC1 DDC1 DIA2
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Topics Genes linked to topics (#11 - 20 )
DUN1 ELG1 GET1 GET2 HST3 HST4 LGE1 MEC3 MRC1 NPT1
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Topics Genes linked to topics (#21 - 30 )
POL32 RAD17 RAD18 RAD24 RAD27 RAD5 RAD53 RAD6 RAD9 RRM3
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Topics Genes linked to topics (#31 - 38 )
SGS1 SKN7 SML1 SOD1 SRS2 TOF1 TSA1 YAP1
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