Mathy G, et al. (2006) Saccharomyces cerevisiae mitoproteome plasticity in response to recombinant alternative ubiquinol oxidase. J Proteome Res 5(2):339-48
Abstract: The energy-dissipating alternative oxidase (AOX) from Hansenula anomala was expressed in Saccharomyces cerevisiae. The recombinant AOX was functional. A comparative analysis by two-dimensional differential in-gel electrophoresis (2D-DIGE) of mitochondrial protein patterns found in wild-type and recombinant AOX strains was performed. 60 proteins exhibiting a significant difference in their abundance were identified. Interestingly, proteins implicated in major metabolic pathways such as Krebs cycle and amino acid biosynthesis were up-regulated. Surprisingly, an up-regulation of the respiratory-chain complex III was associated with a down-regulation of the ATP synthase complex.
|Status: Published||Type: Journal Article||PubMed ID: 16457600|
Topics addressed in this paper
Number of different genes curated to this paper: 19
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|Topics||Genes (#1 - 10 )|
|Topics||Genes (#11 - 19 )|