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Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63

Abstract: Telomeres are nucleoprotein structures present at the ends of eukaryotic chromosomes that play a central role in guarding the integrity of the genome by protecting chromosome ends from degradation and fusion. Length regulation is central to telomere function. To broaden our knowledge about the mechanisms that control telomere length, we have carried out a systematic examination of approximately 4,800 haploid deletion mutants of Saccharomyces cerevisiae for telomere-length alterations. By using this screen, we have identified >150 candidate genes not previously known to affect telomere length. In two-thirds of the identified mutants, short telomeres were observed; whereas in one-third, telomeres were lengthened. The genes identified are very diverse in their functions, but certain categories, including DNA and RNA metabolism, chromatin modification, and vacuolar traffic, are overrepresented. Our results greatly enlarge the number of known genes that affect telomere metabolism and will provide insights into how telomere function is linked to many other cellular processes.

Status: Published Type: Journal Article PubMed ID: 15161972

Topics addressed in this paper

Number of different genes curated to this paper: 147

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADE12 ADO1 AGP2 APE3 ARG2 ARV1 ASC1 ATG11 BEM4 BRE2
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Topics Genes linked to topics (#11 - 20 )
BRO1 BUD16 BUD30 CAX4 CCW14 CDC73 CDH1 CSM1 CST6 CTK1
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Topics Genes linked to topics (#21 - 30 )
DCC1 DEP1 EAP1 ELG1 ERJ5 EST1 EST2 EST3 GCV3 GPB2
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Topics Genes linked to topics (#31 - 40 )
GTR1 GUP1 HCH1 HCM1 HDA2 HPR1 HSC82 HSP104 HST1 HTL1
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Topics Genes linked to topics (#41 - 50 )
HUR1 ISA1 LDB19 LDB7 LEA1 LRP1 LST7 MAK10 MAK3 MAK31
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Topics Genes linked to topics (#51 - 60 )
MET18 MET7 MFT1 MMM1 MOT3 MRE11 MRPL38 MRPL44 MRT4 MTC7
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Topics Genes linked to topics (#61 - 70 )
NAM7 NFI1 NMD2 NPL6 NUP60 OGG1 OPI1 PCP1 PDX3 PEP3
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Topics Genes linked to topics (#71 - 80 )
PHO80 PHO85 PHO87 PIF1 PKP1 POC4 PPE1 PRS3 PTC1 RAD50
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Topics Genes linked to topics (#81 - 90 )
RFM1 RIF1 RIF2 RPB4 RPB9 RPL12B RPL13B RPL1B RPN4 RPP1A
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Topics Genes linked to topics (#91 - 100 )
RPS14A RPS17A RPS4B RRP8 RSC2 RTC1 RTF1 SAP30 SIN3 SIT4
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Topics Genes linked to topics (#101 - 110 )
SMI1 SNF7 SNF8 SOH1 SPS100 SPT21 SRB2 SRB5 SSE1 SSN8
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Topics Genes linked to topics (#111 - 120 )
STO1 STP22 SUM1 SUR4 TAT2 TEL1 THP2 TRK1 UPF3 URE2
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Topics Genes linked to topics (#121 - 130 )
VAM6 VAM7 VPS15 VPS25 VPS28 VPS3 VPS34 VPS36 VPS75 VPS9
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Topics Genes linked to topics (#131 - 140 )
XDJ1 XRN1 XRS2 YDL118W YDR115W YEL057C YGL039W YGR042W YKU70 YKU80
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Topics Genes linked to topics (#141 - 147 )
YMR031W-A YOR008C-A YOR1 YPL041C YPL205C YSP3 YTA7
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