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Swaminathan S, et al.  (2006) Rck2 is required for reprogramming of ribosomes during oxidative stress. Mol Biol Cell 17(3):1472-82

Abstract: Monitoring Editor: Thomas Fox Rck2 is a MAP kinase-regulated protein kinase in yeast implicated in translational regulation. rck2Delta mutants are mildly sensitive to oxidative stress, a condition which causes dissociation of actively translating ribosomes (polysomes). In rck2Delta cells, polysomes are lost to an even higher degree than the wild-type upon stress. Cells overexpressing the catalytically inactive rck2-kDa allele are highly sensitive to oxidative stress. In such cells, dissociation of polysomes upon stress was instead greatly delayed. The protein synthesis rate decreased to a similar degree as in wild-type cells, however, indicating that in rck2-kDa cells, the polysome complexes were inactive. Array analyses of total and polysome-associated mRNAs revealed major deregulation of the translational machinery in rck2 mutant cells. This involves transcripts for cytosolic ribosomal proteins and for processing and assembly of ribosomes. In rck2Delta cells, weakly transcribed mRNAs associate more avidly with polysomes than in wild-type cells, while the opposite holds true for rck2-kDa cells. This is consistent with perturbed regulation of translation elongation, which is predicted to alter the ratio between mRNAs with and without strong entry sites at ribosomes. We infer that imbalances in the translational apparatus are a major reason for the inability of these cells to respond to stress.

Status: Published Type: Journal Article PubMed ID: 16381815

Topics addressed in this paper

Number of different genes curated to this paper: 111

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AHP1 AIM17 ALD3 ARX1 ATC1 BNA3 BRX1 BUD19 BUD28 CLG1
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Topics Genes linked to topics (#11 - 20 )
CLN3 CYS3 DBP3 DDR48 DFM1 EBP2 ESF1 FBA1 FIT2 FMP45
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Topics Genes linked to topics (#21 - 30 )
FSH1 GAS2 GCY1 GLK1 GRE3 GSH1 GSP1 HMX1 HSP150 HSP42
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Topics Genes linked to topics (#31 - 40 )
HXK1 HXT2 IDP3 IPT1 KRE2 LAS17 LRP1 MET10 MET14 MET17
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Topics Genes linked to topics (#41 - 50 )
MET3 MET32 MET6 MIG2 MMP1 MRT4 MSC1 NHP2 NOP13 NOP15
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Topics Genes linked to topics (#51 - 60 )
NOP56 NOP58 NOP6 NOP7 PAP1 PHD1 PHO3 PNC1 PNS1 PPH21
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Topics Genes linked to topics (#61 - 70 )
RCK2 RPF2 RPL11B RPL17A RPL17B RPL19B RPL21B RPL24B RPL34A RPL34B
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Topics Genes linked to topics (#71 - 80 )
RPL35A RPL38 RPL39 RPL9A RPS27A RPS6A RPS7A RTC3 SER33 SPO12
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Topics Genes linked to topics (#81 - 90 )
SSB1 TDH3 TMA10 TPS1 TPS2 TRA1 TRX2 TSL1 UTP14 UTP23
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Topics Genes linked to topics (#91 - 100 )
UTP4 UTP6 UTP9 YCL042W YDL023C YDL124W YDR133C YDR476C YJL163C YJR027W
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Topics Genes linked to topics (#101 - 110 )
YKL097C YLR042C YLR198C YLR269C YLR302C YMR173W-A YMR321C YNL134C YNL174W YNR040W
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Topics Genes linked to topics (#111 )
YPL162C
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