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Willingham S, et al.  (2003) Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science 302(5651):1769-72

Abstract: Genome-wide screens were performed in yeast to identify genes that enhance the toxicity of a mutant huntingtin fragment or of alpha-synuclein. Of 4850 haploid mutants containing deletions of nonessential genes, 52 were identified that were sensitive to a mutant huntingtin fragment, 86 that were sensitive to alpha-synuclein, and only one mutant that was sensitive to both. Genes that enhanced toxicity of the mutant huntingtin fragment clustered in the functionally related cellular processes of response to stress, protein folding, and ubiquitin-dependent protein catabolism, whereas genes that modified alpha-synuclein toxicity clustered in the processes of lipid metabolism and vesicle-mediated transport. Genes with human orthologs were overrepresented in our screens, suggesting that we may have discovered conserved and nonoverlapping sets of cell-autonomous genes and pathways that are relevant to Huntington's disease and Parkinson's disease.

Status: Published Type: Journal Article PubMed ID: 14657499

Topics addressed in this paper

Number of different genes curated to this paper: 137

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ABZ2 AIM46 ALB1 APE2 APJ1 APM2 ARL3 ARO1 ATG15 AYR1
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Disease Gene Related yg ball
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Topics Genes linked to topics (#11 - 20 )
CIT2 CMK1 COG6 COS111 CPS1 CRH1 DCG1 DCN1 DPP1 EMC4
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Topics Genes linked to topics (#21 - 30 )
FPR2 FUN26 GDA1 GIP2 GLO2 GLO4 GRE2 GSH2 GTO1 GTT1
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Cross-species Expression blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
HBS1 HEL1 HLJ1 HLR1 HMS1 HSP30 INO4 IPK1 KGD1 MAD1
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Topics Genes linked to topics (#41 - 50 )
MAL31 MEI4 MET17 MET32 MRPL11 MSB1 MSB3 MTC2 MTC3 MTC4
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Topics Genes linked to topics (#51 - 60 )
MUP1 NBP2 NIT2 NPP1 NUP53 OAF3 OPI3 OPI8 PCA1 PCL6
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Topics Genes linked to topics (#61 - 70 )
PEX2 PEX8 PHM8 PHO13 POX1 PRM5 PSP1 PSY3 PTK2 RIM4
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Topics Genes linked to topics (#71 - 80 )
RNY1 RPL41A RRF1 SAM2 SAP4 SAS3 SDT1 SIP18 SNG1 SOD2
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Topics Genes linked to topics (#81 - 90 )
STF1 STP2 SUV3 SWR1 TEA1 THI7 THR1 TLG2 TNA1 TSL1
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Topics Genes linked to topics (#91 - 100 )
TVP15 UBC8 UBP13 VPS24 VPS28 VPS52 VPS60 VPS70 WAR1 YAT1
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Topics Genes linked to topics (#101 - 110 )
YBR013C YBR100W YBR284W YBR300C YCL042W YCR050C YCR051W YCR085W YDL118W YDR154C
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Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#111 - 120 )
YDR215C YDR220C YFR035C YGL109W YGL165C YGL262W YGR015C YGR130C YGR201C YGR290W
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Topics Genes linked to topics (#121 - 130 )
YHB1 YJL118W YJL135W YJR107W YJR154W YKL100C YKR023W YLR365W YML089C YMR160W
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Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#131 - 137 )
YMR226C YNL296W YOR292C YOR300W YPL067C YPL136W YRB30
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Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball

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