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Cai H, et al.  (2006) Genomewide Screen Reveals a Wide Regulatory Network for Di/Tripeptide Utilization in Saccharomyces cerevisiae. Genetics 172(3):1459-76

Abstract: Small peptides of two to six residues serve as important sources of amino acids and nitrogen required for growth by a variety of organisms. In the yeast Saccharomyces cerevisiae, the membrane transport protein Ptr2p, encoded by PTR2, mediates the uptake of di/tri-peptides. To identify genes involved in regulation of dipeptide utilization, we performed a systematic, functional examination of this process in a haploid, non-essential, single-gene deletion mutant library. We have identified 103 candidate genes: 57 genes whose deletion decreased dipeptide utilization and 46 genes whose deletion enhanced dipeptide utilization. Based on Ptr2p-GFP expression studies, together with PTR2 expression analysis and dipeptide uptake assays, 41 genes were ascribed to the regulation of PTR2 expression, 38 genes were involved in Ptr2p localization, and 24 genes did not apparently affect Ptr2p-GFP expression or localization. The 103 genes regulating dipeptide utilization were distributed among most of the Gene Ontology functional categories indicating a very wide regulatory network involved in transport and utilization of dipeptides in yeast. It is anticipated that further characterization of how these genes affect peptide utilization should add new insights into the global mechanisms of regulation of transport systems in general and peptide utilization in particular.

Status: Published Type: Journal Article PubMed ID: 16361226

Topics addressed in this paper

Number of different genes curated to this paper: 90

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AIM22 ARP5 ARP8 ASM4 AVL9 BEM4 BNI1 BUD32 CSF1 CSM1
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Topics Genes linked to topics (#11 - 20 )
CUP9 DAL81 DBR1 DEF1 DID4 DUG1 EAF3 EAF7 ETR1 GCV2
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Topics Genes linked to topics (#21 - 30 )
GCV3 HAL9 HFM1 HOF1 HTD2 IES6 ILM1 IPK1 ISA1 ISA2
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Topics Genes linked to topics (#31 - 40 )
LDB19 LPD1 LST4 MCK1 MRE11 MRPS9 NFU1 NMA111 NPL3 NPR1
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Topics Genes linked to topics (#41 - 50 )
PAT1 PHO85 PMA1 PTR2 RAD6 REG1 RPL21A RPN4 RPS9B SAC6
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Topics Genes linked to topics (#51 - 60 )
SFP1 SHM2 SHP1 SNF7 SNF8 SRB8 SRN2 SSD1 SSN2 SSN3
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Topics Genes linked to topics (#61 - 70 )
SSN8 STP2 STP22 SUR4 TAF14 THP1 TOM71 TPM1 TSA1 UBA3
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UBP14 UBR1 UBR2 VAM10 VPS20 VPS24 VPS25 VPS28 VPS36 VPS8
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Topics Genes linked to topics (#81 - 90 )
XRN1 YBT1 YDR015C YDR157W YDR290W YDR433W YJL175W YNL295W YPL073C YPR174C
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