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Tripic T, et al.  (2006) The Set2 methyltransferase associates with Ssn6 yet Tup1-Ssn6 repression is independent of histone methylation. Biochem Biophys Res Commun 339(3):905-14

Abstract: The Tup1-Ssn6 corepressor regulates the expression of diverse classes of genes in Saccharomyces cerevisiae. Chromatin is an important component of Tup1-Ssn6-mediated repression. Tup1 binds to underacetylated tails of histones H3 and H4, and requires multiple histone deacetylases for the repression. Here we examine if histone methylation, in addition to histone deacetylation, plays a role in Tup1-Ssn6 repression. We found that like other genes, Tup1-Ssn6 target genes exhibit increased levels of histone H3 lysine 4 trimethylation upon activation. However, deletion of individual or multiple histone methyltransferases and other SET-domain containing genes has no apparent effect on Tup1-Ssn6-mediated repression of a number of well-defined targets. Interestingly, we discovered that Ssn6 interacts with Set2. Although deletion of SET2 does not affect Tup1-Ssn6 repression of a number of target genes, Ssn6 may utilize Set2 in specific contexts to regulate gene repression.

Status: Published Type: Journal Article PubMed ID: 16329992

Topics addressed in this paper

Number of different genes curated to this paper: 19

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Topics Genes linked to topics (#1 - 10 )
CYC8 DOT1 HHF1 HHF2 HHT1 HHT2 HOS2 MFA2 RKM4 RNR2
Additional Literature blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Protein Processing/Modification/Regulation blue ball blue ball
Protein Sequence Features blue ball
Protein-Nucleic Acid Interactions blue ball blue ball
Protein-protein Interactions blue ball
Regulation of blue ball blue ball
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Topics Genes linked to topics (#11 - 19 )
SET1 SET2 SET3 SET4 SET5 SET6 STE6 SUC2 TUP1
Additional Literature blue ball blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball
Protein Sequence Features blue ball
Protein-protein Interactions blue ball
Regulation of blue ball blue ball
Regulatory Role blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Transcription blue ball

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