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Lee D, et al.  (2005) The proteasome regulatory particle alters the SAGA coactivator to enhance its interactions with transcriptional activators. Cell 123(3):423-36

Abstract: Promoter recruitment of the Saccharomyces cerevisiae SAGA histone acetyltransferase complex is required for RNA polymerase II-dependent transcription of several genes. SAGA is targeted to promoters through interactions with sequence-specific DNA binding transcriptional activators and facilitates preinitiation-complex assembly and transcription. Here, we show that the 19S proteasome regulatory particle (19S RP) alters SAGA to stimulate its interaction with transcriptional activators. The ATPase components of the 19S RP are required for stimulation of SAGA/activator interactions and enhance SAGA recruitment to promoters. Proteasomal ATPases genetically interact with SAGA, and their inhibition reduces global histone H3 acetylation levels and SAGA recruitment to target promoters in vivo. These results indicate that the 19S RP modulates SAGA complex using its ATPase components, thereby facilitating subsequent transcription events at promoters.

Status: Published Type: Journal Article PubMed ID: 16269334

Topics addressed in this paper

Number of different genes curated to this paper: 42

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Topics Genes linked to topics (#1 - 10 )
ADA2 CHD1 GCN5 HFI1 NGG1 RPN1 RPN10 RPN11 RPN12 RPN13
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Topics Genes linked to topics (#11 - 20 )
RPN2 RPN3 RPN4 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2
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Topics Genes linked to topics (#21 - 30 )
RPT3 RPT4 RPT5 RPT6 RTG2 SEM1 SGF11 SGF29 SGF73 SPT20
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Topics Genes linked to topics (#31 - 40 )
SPT3 SPT7 SPT8 SUS1 TAF10 TAF12 TAF5 TAF6 TAF9 TRA1
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Topics Genes linked to topics (#41 - 42 )
UBP6 UBP8
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