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Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15

Abstract: We report the characterization of early pre-ribosomal particles. Twelve TAP-tagged components each showed nucleolar localization, sedimented at approximately 90S on sucrose gradients, and coprecipitated both the 35S pre-rRNA and the U3 snoRNA. Thirty-five non-ribosomal proteins were coprecipitated, including proteins associated with U3 (Nop56p, Nop58p, Sof1p, Rrp9, Dhr1p, Imp3p, Imp4p, and Mpp10p) and other factors required for 18S rRNA synthesis (Nop14p, Bms1p, and Krr1p). Mutations in components of the 90S pre-ribosomes impaired 40S subunit assembly and export. Strikingly, few components of recently characterized pre-60S ribosomes were identified in the 90S pre-ribosomes. We conclude that the 40S synthesis machinery predominately associates with the 35S pre-rRNA factors, whereas factors required for 60S subunit synthesis largely bind later, showing an unexpected dichotomy in binding.

Status: Published Type: Journal Article PubMed ID: 12150911

Topics addressed in this paper

Number of different genes curated to this paper: 94

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Topics Genes linked to topics (#1 - 10 )
BFR2 BMS1 BUD21 CBF5 CMS1 DBP8 DIM1 DIP2 ECM16 EMG1
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ENP1 ENP2 HAS1 IMP3 IMP4 KRE33 KRR1 MPP10 MRD1 NAN1
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NOC4 NOP1 NOP14 NOP4 NOP56 NOP58 NOP6 PNO1 PRP43 PWP2
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Topics Genes linked to topics (#31 - 40 )
RCL1 RDN37-1 RDN37-2 ROK1 RPL10 RPL11A RPL17A RPL20A RPL20B RPL30
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Topics Genes linked to topics (#41 - 50 )
RPL4A RPL4B RPL5 RPL7B RPP0 RPS0A RPS11A RPS11B RPS13 RPS14A
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Topics Genes linked to topics (#51 - 60 )
RPS16A RPS17A RPS17B RPS18A RPS1A RPS1B RPS2 RPS22A RPS22B RPS24A
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Topics Genes linked to topics (#61 - 70 )
RPS24B RPS28B RPS3 RPS4A RPS4B RPS5 RPS6A RPS7A RPS8A RPS8B
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Topics Genes linked to topics (#71 - 80 )
RPS9A RPS9B RRP12 RRP45 RRP5 RRP9 SCL1 SNR17A SNR17B SOF1
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Topics Genes linked to topics (#81 - 90 )
TSR1 UTP10 UTP13 UTP15 UTP18 UTP20 UTP21 UTP22 UTP30 UTP4
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Topics Genes linked to topics (#91 - 94 )
UTP6 UTP7 UTP8 UTP9
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