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Alexandre H, et al.  (2001) Global gene expression during short-term ethanol stress in Saccharomyces cerevisiae. FEBS Lett 498(1):98-103

Abstract: DNA microarrays were used to investigate the expression profile of yeast genes in response to ethanol. Up to 3.1% of the genes encoded in the yeast genome were up-regulated by at least a factor of three after 30 min ethanol stress (7% v/v). Concomitantly, 3.2% of the genes were down-regulated by a factor of three. Of the genes up-regulated in response to ethanol 49.4% belong to the environmental stress response and 14.2% belong to the stress gene family. Our data show that in addition to the previously identified ethanol-induced genes, a very large number of genes involved in ionic homeostasis, heat protection, trehalose synthesis and antioxidant defence also respond to ethanol stress. It appears that a large number of the up-regulated genes are involved in energy metabolism. Thus, 'management' of the energy pool (especially ATP) seems to constitute an ethanol stress response and to involve different mechanisms.

Status: Published Type: Journal Article PubMed ID: 11389906

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Number of different genes curated to this paper: 62

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AHP1 ALD2 ALD4 APJ1 ATG8 CCC2 CDC19 CIT1 CIT2 CPR6
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CTT1 DAK1 EMI2 ERO1 EUG1 GDB1 GIP2 GLC3 GLG1 GLK1
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GPD1 GPH1 GPM2 GSY1 HOR2 HOR7 HSP30 HSP42 HSP78 HSP82
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Topics Genes linked to topics (#31 - 40 )
HXK1 IMA2 LHS1 MCR1 NTH1 OYE2 OYE3 PAU13 PBI2 PDI1
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PFK26 PGM2 PIC2 PRB1 RPN4 SIA1 SPF1 SSA1 SSA2 SSE1
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STF1 STF2 TDH1 TPS1 TPS2 TSL1 UBC8 UGP1 YBR139W YMR018W
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Topics Genes linked to topics (#61 - 62 )
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