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Verstrepen KJ, et al.  (2005) Intragenic tandem repeats generate functional variability. Nat Genet 37(9):986-90

Abstract: Tandemly repeated DNA sequences are highly dynamic components of genomes. Most repeats are in intergenic regions, but some are in coding sequences or pseudogenes. In humans, expansion of intragenic triplet repeats is associated with various diseases, including Huntington chorea and fragile X syndrome. The persistence of intragenic repeats in genomes suggests that there is a compensating benefit. Here we show that in the genome of Saccharomyces cerevisiae, most genes containing intragenic repeats encode cell-wall proteins. The repeats trigger frequent recombination events in the gene or between the gene and a pseudogene, causing expansion and contraction in the gene size. This size variation creates quantitative alterations in phenotypes (e.g., adhesion, flocculation or biofilm formation). We propose that variation in intragenic repeat number provides the functional diversity of cell surface antigens that, in fungi and other pathogens, allows rapid adaptation to the environment and elusion of the host immune system.

Status: Published Type: Journal Article PubMed ID: 16086015

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MNN4 MSB2 MSS11 NAB2 NDD1 NOP1 NUD1 NUM1 PCF11 PIR1
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PIR3 PUF3 SCT1 SCW11 SED1 SLA1 SPA2 TIR1 TIR4 UBI4
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WSC3 YAR062W YIL080W YNL190W ZRG8
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