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Wong SL and Roth FP  (2005) Transcriptional compensation for gene loss plays a minor role in maintaining genetic robustness in Saccharomyces cerevisiae. Genetics 171(2):829-33

Abstract: If a gene is mutated and its function lost, are compensatory genes upregulated? We investigated whether genes are transcriptionally upregulated when their synthetic sick or lethal (SSL) partners are lost. We identified several new examples, however, remarkably few SSL pairs exhibited this phenomenon, suggesting that transcriptional compensation by SSL partners is a rare mechanism for maintaining genetic robustness.

Status: Published Type: Journal Article PubMed ID: 15998714

Topics addressed in this paper

Number of different genes curated to this paper: 17

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ARC40 BNI1 CDC42 CHS3 CHS7 FKS1 FLC2 GAS1 GIC2 GSC2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genomic expression study yg ball
Large-scale genetic interaction yg ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball
Omics yg ball
Regulation of blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 17 )
MID2 RIM21 RLM1 SHE4 SLT2 TRS65 YMR316C-A
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball
Regulation of blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball

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