Wong SL and Roth FP (2005) Transcriptional compensation for gene loss plays a minor role in maintaining genetic robustness in Saccharomyces cerevisiae. Genetics 171(2):829-33
Abstract: If a gene is mutated and its function lost, are compensatory genes upregulated? We investigated whether genes are transcriptionally upregulated when their synthetic sick or lethal (SSL) partners are lost. We identified several new examples; however, remarkably few SSL pairs exhibited this phenomenon, suggesting that transcriptional compensation by SSL partners is a rare mechanism for maintaining genetic robustness.
|Status: Published||Type: Comparative Study | Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't||PubMed ID: 15998714|
Topics addressed in this paper
Number of different genes curated to this paper: 17
- To go to the Locus page for a gene, click on the gene name.
|Topics||Topics not linked to Genes||Genes (#1 - 10 )|
|Genomic expression study|
|Large-scale genetic interaction|
|Topics||Genes (#11 - 17 )|