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Morillon A, et al.  (2005) Dynamic lysine methylation on histone H3 defines the regulatory phase of gene transcription. Mol Cell 18(6):723-34

Abstract: Covalent modifications to histones are key epigenetic marks that control gene transcription. Multiple lysine residues on histone H3 are methylated (me), but their functions are unclear. Here, we demonstrate two phases of combinatorial and dynamic H3 methylation during induction of transcription at MET16 in yeast. K4me3 with K36me2/3 define a postinitiation regulatory phase and precede the appearance of K4me2 with K79me2 at the onset of transcript elongation. The Isw1 ATPase delays the release of initiated RNA polymerase II (RNAPII) into elongation to facilitate chromatin modifications. The Spp1 subunit of complex associated with Set1 (COMPASS) and Set2, determining K4me3 and K36me2/3, respectively, are required for transient NuA4-dependent H4K8ac. This releases RNAPII from Isw1 control and promotes controlled transcription elongation and termination. We propose that newly initiated RNAPII is under epigenetic control.

Status: Published Type: Journal Article PubMed ID: 15949446

Topics addressed in this paper

Number of different genes curated to this paper: 13

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Topics Genes linked to topics (#1 - 10 )
BRE1 ESA1 ISW1 MET16 PAF1 RAD6 RPO21 SDC1 SET1 SET2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Primary Literature blue ball blue ball blue ball blue ball
Protein Processing/Modification/Regulation blue ball
Protein Sequence Features blue ball
Protein-Nucleic Acid Interactions blue ball blue ball blue ball
Regulation of blue ball blue ball
Regulatory Role blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Transcription blue ball

Topics Genes linked to topics (#11 - 13 )
SPP1 SWD1 SWD3
Additional Literature blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball

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