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van Bakel H, et al.  (2005) Gene expression profiling and phenotype analyses of S. cerevisiae in response to changing copper reveals six genes with new roles in copper and iron metabolism. Physiol Genomics 22(3):356-67

Abstract: Exhaustive microarray time-course analyses of S.cerevisiae during copper starvation and copper excess reveal new aspects of metal-induced gene regulation. Besides identifying targets of established copper- and iron-responsive transcription factors, we find that genes encoding mitochondrial proteins are down-regulated and that copper-independent iron transport genes are preferentially upregulated, both during prolonged copper deprivation. The experiments also suggest the presence of a small regulatory iron pool that links copper and iron responses. 128 genes with putative roles in metal metabolism were further investigated by several systematic phenotype screens. Of the novel phenotypes uncovered, hsp12-Delta and arn1-Delta display increased sensitivity to copper, cyc1-Delta and crr1-Delta show resistance to high copper, vma13-Delta exhibits increased sensitivity to iron deprivation, and pep12-Delta results in reduced growth in high copper and low iron. Besides revealing new components of eukaryotic metal trafficking pathways, the results underscore the previously determined intimate links between iron and copper metabolism, mitochondrial and vacuolar function in metal trafficking. The analyses further suggest that copper starvation can specifically lead to down-regulation of respiratory function to preserve iron and copper for other cellular processes.

Status: Published Type: Journal Article PubMed ID: 15886332

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Number of different genes curated to this paper: 127

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AFT1 AFT2 AGA1 AGA2 AKR1 ALD3 ALD5 AMS1 APE2 AQY2
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Genomic expression study yg ball
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Topics Genes linked to topics (#11 - 20 )
ARG1 ARN1 ARN2 ATP7 BAG7 CCC2 CIR2 COP1 COT1 CPS1
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Topics Genes linked to topics (#21 - 30 )
CRR1 CRS5 CTR1 CUP1-1 CUP1-2 CUP2 CWP1 CYC1 CYT1 DDR2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
DLD2 ECL1 ENB1 FET3 FET4 FIT2 FIT3 FMP23 FMP48 FRE1
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Topics Genes linked to topics (#41 - 50 )
FRE2 FRE6 FRE7 FRE8 FTH1 FTR1 FUS1 GAD1 GDB1 GPG1
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Topics Genes linked to topics (#51 - 60 )
GPH1 GRX4 GSC2 GTO3 HBT1 HOR7 HSP12 HUR1 HXK1 ICY1
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Topics Genes linked to topics (#61 - 70 )
ICY2 IRC7 ISU2 LEU1 MAC1 MRS4 MSC1 NDT80 NRP1 OLI1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#71 - 80 )
OPT2 OYE3 PBI2 PCL5 PEP12 PHO89 PIC2 POT1 PRM1 PTR2
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Topics Genes linked to topics (#81 - 90 )
RBS1 REE1 REX3 RIP1 SDH4 SEF1 SFA1 SIT1 SMF3 SNO4
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#91 - 100 )
SPI1 STF2 STP4 TDA6 TFS1 TIS11 TMT1 TPO2 VHT1 VMA13
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#101 - 110 )
VMR1 YAL064W-B YBR285W YCL042W YCR102C YDR222W YDR239C YER156C YET2 YGR182C
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Topics Genes linked to topics (#111 - 120 )
YHB1 YIL169C YIR040C YJR096W YLR126C YLR162W YLR297W YOR012W YOR062C YOR289W
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Topics Genes linked to topics (#121 - 127 )
YOR296W YOR338W YOR364W YOR389W YPL014W YPL277C YPL278C
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