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Tackett AJ, et al.  (2005) Proteomic and genomic characterization of chromatin complexes at a boundary. J Cell Biol 169(1):35-47

Abstract: We have dissected specialized assemblies on the Saccharomyces cerevisiae genome that help define and preserve the boundaries that separate silent and active chromatin. These assemblies contain characteristic stretches of DNA that flank particular regions of silent chromatin, as well as five distinctively modified histones and a set of protein complexes. The complexes consist of at least 15 chromatin-associated proteins, including DNA pol epsilon, the Isw2-Itc1 and Top2 chromatin remodeling proteins, the Sas3-Spt16 chromatin modifying complex, and Yta7, a bromodomain-containing AAA ATPase. We show that these complexes are important for the faithful maintenance of an established boundary, as disruption of the complexes results in specific, anomalous alterations of the silent and active epigenetic states.

Status: Published Type: Journal Article PubMed ID: 15824130

Topics addressed in this paper

Number of different genes curated to this paper: 24

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Topics Genes linked to topics (#1 - 10 )
CTF18 DLS1 DPB2 DPB3 DPB4 HHF1 HHF2 HHT1 HHT2 HTA1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball
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Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
HTA2 HTB1 HTB2 HTZ1 ISW2 ITC1 POL2 RFC1 RPB2 SAS3
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball
Function/Process blue ball
Primary Literature blue ball
Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 24 )
SPT16 TOP2 YLR455W YTA7
Additional Literature blue ball blue ball blue ball
Primary Literature blue ball
Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball

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