Resnick MA (2005) Reduced replication: a call to ARMS. Cell 120(5):569-70
Abstract: In this issue of Cell, Lemoine et al. monitor chromosome instability in yeast cells with reduced levels of an essential replicative DNA polymerase. The authors identify a hotspot for chromosome aberrations reminiscent of fragile sites in human cells. This hotspot is composed of inverted Ty elements, which lead to a double-strand break under conditions of limited replication.
|Status: Published||Type: Comment | Journal Article||PubMed ID: 15766518|
Topics addressed in this paper
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