SGD Paper 
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Hakamata W, et al. (2005) Aglycon specificity profiling of alpha-glucosidases using synthetic probes. Bioorg Med Chem Lett 15(5):1489-92
Abstract: We designed and synthesized hydrogen bond based probes 1-8 with the exception of known glycosidase inhibition mechanisms, and aglycon specificity of 11 different sources of alpha-glucosidases were investigated using their probes. Probe 4 (2,6-anhydro-1-deoxy-1-[(1-oxopentyl-5-hydroxy)amino]-d-glycero-d-ido-hept itol) showed a potent inhibition of S. cerevisiae alpha-glucosidase among all alpha-glucosidases. Probe 4 was found to be a competitive inhibitor for S. cerevisiae alpha-glucosidase with K(i) 0.13mM.
| Status: Published | Type: Journal Article | PubMed ID: 15713413 |
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