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Schwabish MA and Struhl K  (2004) Evidence for eviction and rapid deposition of histones upon transcriptional elongation by RNA polymerase II. Mol Cell Biol 24(23):10111-7

Abstract: Biochemical experiments indicate that transcriptional elongation by RNA polymerase II (Pol II) is inhibited by nucleosomes and hence requires chromatin-modifying activities. Here, we examine the fate of histones upon passage of elongating Pol II in vivo. Histone density throughout the entire Saccharomyces cerevisiae GAL10 coding region is inversely correlated with Pol II association and transcriptional activity, suggesting that the elongating Pol II machinery efficiently evicts core histones from the DNA. Furthermore, new histones appear to be deposited onto DNA less than 1 min after passage of Pol II. Transcription-dependent deposition of histones requires the FACT complex that travels with elongating Pol II. Our results suggest that Pol II transcription generates a highly dynamic equilibrium of histone eviction and histone deposition and that there is significant histone exchange throughout most of the yeast genome within a single cell cycle.

Status: Published Type: Journal Article PubMed ID: 15542822

Topics addressed in this paper

Number of different genes curated to this paper: 29

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Topics Genes linked to topics (#1 - 10 )
CDC73 CHD1 CTR9 ELF1 ELP2 ELP3 ELP4 ELP6 GAL10 HHF1
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DNA/RNA Sequence Features blue ball
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Topics Genes linked to topics (#11 - 20 )
HHF2 HHT1 HHT2 HTA1 HTA2 IKI1 IKI3 KIN28 LEO1 NHP6A
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Topics Genes linked to topics (#21 - 29 )
NHP6B PAF1 POB3 RTF1 SPN1 SPT16 SPT4 SPT5 SPT6
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Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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