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Wu PY, et al.  (2004) Molecular architecture of the S. cerevisiae SAGA complex. Mol Cell 15(2):199-208

Abstract: The Saccharomyces cerevisiae SAGA complex is a multifunctional coactivator that regulates transcription by RNA polymerase II. The 3D structure of SAGA, revealed by electron microscopy, is formed by five modular domains and shows a high degree of structural conservation to human TFTC, reflecting their related subunit composition. The positions of several SAGA subunits were mapped by immunolabeling and by analysis of mutant complexes. The Taf (TBP-associated factor) subunits, shared with TFIID, occupy a central region in SAGA and form a similar structure in both complexes. The locations of two histone fold-containing core subunits, Spt7 and Ada1, are consistent with their role in providing a SAGA-specific interface with the Tafs. Three components that perform distinct regulatory functions, Spt3, Gcn5, and Tra1, are spatially separated, underscoring the modular nature of the complex. Our data provide insights into the molecular architecture of SAGA and imply a functional organization to the complex.

Status: Published Type: Journal Article PubMed ID: 15260971

Topics addressed in this paper

Number of different genes curated to this paper: 21

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Topics Genes linked to topics (#1 - 10 )
ADA2 CHD1 GCN5 HFI1 NGG1 SGF11 SGF29 SGF73 SPT15 SPT20
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Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Regulation of blue ball

Topics Genes linked to topics (#11 - 20 )
SPT3 SPT7 SPT8 SUS1 TAF10 TAF12 TAF5 TAF6 TAF9 TRA1
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Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein/Nucleic Acid Structure blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 )
UBP8
Additional Literature blue ball
Cellular Location blue ball
Function/Process blue ball
Protein Sequence Features blue ball
Protein-protein Interactions blue ball
Protein/Nucleic Acid Structure blue ball

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