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Horsey EW, et al.  (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27

Abstract: The Saccharomyces cerevisiae gene RRP1 encodes an essential, evolutionarily conserved protein necessary for biogenesis of 60S ribosomal subunits. Processing of 27S pre-ribosomal RNA to mature 25S rRNA is blocked and 60S subunits are deficient in the temperature-sensitive rrp1-1 mutant. We have used recent advances in proteomic analysis to examine in more detail the function of Rrp1p in ribosome biogenesis. We show that Rrp1p is a nucleolar protein associated with several distinct 66S pre-ribosomal particles. These pre-ribosomes contain ribosomal proteins plus at least 28 nonribosomal proteins necessary for production of 60S ribosomal subunits. Inactivation of Rrp1p inhibits processing of 27SA(3) to 27SB(S) pre-rRNA and of 27SB pre-rRNA to 7S plus 25.5S pre-rRNA. Thus, in the rrp1-1 mutant, 66S pre-ribosomal particles accumulate that contain 27SA(3) and 27SB(L) pre-ribosomal RNAs.

Status: Published Type: Journal Article PubMed ID: 15100437

Topics addressed in this paper

Number of different genes curated to this paper: 81

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Topics Genes linked to topics (#1 - 10 )
BRX1 CIC1 DBP10 DRS1 EBP2 ERB1 HAS1 LOC1 MAK16 MAK21
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Topics Genes linked to topics (#11 - 20 )
NIP7 NOC2 NOG1 NOP15 NOP16 NOP2 NOP4 NOP7 NSA1 NSA2
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Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
RLP7 RPF1 RPF2 RPL10 RPL11A RPL11B RPL12A RPL12B RPL13A RPL13B
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Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
RPL15A RPL15B RPL17A RPL17B RPL18A RPL18B RPL19A RPL19B RPL20A RPL20B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#41 - 50 )
RPL21A RPL21B RPL23A RPL23B RPL24A RPL24B RPL25 RPL26A RPL26B RPL27A
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#51 - 60 )
RPL27B RPL28 RPL2A RPL2B RPL3 RPL30 RPL32 RPL33A RPL33B RPL36A
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#61 - 70 )
RPL36B RPL43A RPL43B RPL4A RPL4B RPL5 RPL6A RPL6B RPL8A RPL8B
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Topics Genes linked to topics (#71 - 80 )
RPS1A RPS1B RPS3 RPS8A RPS8B RRP1 RRP14 RRP5 SSF1 TIF6
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Strains/Constructs blue ball

Topics Genes linked to topics (#81 )
YTM1
Cellular Location blue ball
Primary Literature blue ball
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