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Chang M, et al.  (2002) A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc Natl Acad Sci U S A 99(26):16934-9

Abstract: We performed a systematic screen of the set of approximately 5,000 viable Saccharomyces cerevisiae haploid gene deletion mutants and have identified 103 genes whose deletion causes sensitivity to the DNA-damaging agent methyl methanesulfonate (MMS). In total, 40 previously uncharacterized alkylation damage response genes were identified. Comparison with the set of genes known to be transcriptionally induced in response to MMS revealed surprisingly little overlap with those required for MMS resistance, indicating that transcriptional regulation plays little, if any, role in the response to MMS damage. Clustering of the MMS response genes on the basis of their cross-sensitivities to hydroxyurea, UV radiation, and ionizing radiation revealed a DNA damage core of genes required for responses to a broad range of DNA-damaging agents. Of particular significance, we identified a subset of genes that show a specific MMS response, displaying defects in S phase progression only in the presence of MMS. These genes may promote replication fork stability or processivity during encounters between replication forks and DNA damage.

Status: Published Type: Journal Article PubMed ID: 12482937

Topics addressed in this paper

Number of different genes curated to this paper: 103

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AAT2 APN1 ARO1 ARO7 ASF1 BDF1 BUD25 BUR2 CAC2 CCS1
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Large-scale phenotype analysis yg ball
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Topics Genes linked to topics (#11 - 20 )
CDC40 CDC50 CHL1 CIK1 COA4 CSE2 CTF18 CTF4 CTF8 DCC1
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Topics Genes linked to topics (#21 - 30 )
DDC1 DEF1 DEG1 DOA1 DUN1 EAF1 ERG3 FMP33 GRR1 HOF1
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Topics Genes linked to topics (#31 - 40 )
HPR1 HTL1 ISC1 LDB7 LSM1 LSM6 MAG1 MEC3 MED1 MET18
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Topics Genes linked to topics (#41 - 50 )
MMS1 MMS2 MMS22 MMS4 MRE11 MUS81 NAT3 NPL6 NUP133 NUP84
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Topics Genes linked to topics (#51 - 60 )
POL32 PSY3 RAD1 RAD17 RAD18 RAD24 RAD27 RAD5 RAD50 RAD51
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Topics Genes linked to topics (#61 - 70 )
RAD52 RAD54 RAD55 RAD57 RAD59 RAD6 RAD9 REV3 RIM20 RMI1
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Topics Genes linked to topics (#71 - 80 )
RPB9 RRN10 RTT101 RTT107 RTT109 SAE2 SAM37 SEC66 SGS1 SIT4
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Topics Genes linked to topics (#81 - 90 )
SLX4 SOD1 SPT4 SRB2 SRB5 SRS2 SWC5 SWI6 TAF14 TOP3
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Topics Genes linked to topics (#91 - 100 )
UBC13 UBP6 UME6 VMA21 VPS36 XRS2 YBR099C YCK3 YDR433W YEL045C
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Topics Genes linked to topics (#101 - 103 )
YLR235C YMC2 YMR031W-A
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