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Vermeulen M, et al.  (2004) In vitro targeting reveals intrinsic histone tail specificity of the Sin3/histone deacetylase and N-CoR/SMRT corepressor complexes. Mol Cell Biol 24(6):2364-72

Abstract: The histone code is among others established via differential acetylation catalyzed by histone acetyltransferases (HATs) and histone deacetylases (HDACs). To unambiguously determine the histone tail specificity of HDAC-containing complexes, we have established an in vitro system consisting of nucleosomal templates reconstituted with hyperacetylated histones or recombinant histones followed by acetylation with native SAGA or NuA4. Selective targeting of the mammalian Sin3/HDAC and N-CoR/SMRT corepressor complexes by using specific chimeric repressors created a near physiological setting to assess their histone tail specificity. Recruitment of the Sin3/HDAC complex to nucleosomal templates preacetylated with SAGA or NuA4 resulted in deacetylation of histones H3 and H4, whereas recruitment of N-CoR/SMRT resulted in deacetylation of histone H3 only. These results provide solid evidence that HDAC-containing complexes display distinct, intrinsic histone tail specificities and hence may function differently to regulate chromatin structure and transcription.

Status: Published Type: Journal Article PubMed ID: 14993276

Topics addressed in this paper

Number of different genes curated to this paper: 34

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Topics Genes linked to topics (#1 - 10 )
ACT1 ADA2 ARP4 CHD1 EAF1 EAF3 EAF5 EAF6 EAF7 EPL1
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Topics Genes linked to topics (#11 - 20 )
ESA1 GCN5 HFI1 NGG1 SAP30 SGF11 SGF29 SGF73 SIN3 SPT20
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Topics Genes linked to topics (#21 - 30 )
SPT3 SPT7 SPT8 SUS1 SWC4 TAF10 TAF12 TAF5 TAF6 TAF9
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Topics Genes linked to topics (#31 - 34 )
TRA1 UBP8 YAF9 YNG2
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