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Strawn LA, et al.  (2004) Minimal nuclear pore complexes define FG repeat domains essential for transport. Nat Cell Biol 6(3):197-206

Abstract: Translocation through nuclear pore complexes (NPCs) requires interactions between receptor-cargo complexes and phenylalanine-glycine (FG) repeats in multiple FG domain-containing NPC proteins (FG-Nups). We have systematically deleted the FG domains of 11 Saccharomyces cerevisiae FG-Nups in various combinations. All five asymmetrically localized FG domains deleted together were non-essential. However, specific combinations of symmetrically localized FG domains were essential. Over half the total mass of FG domains could be deleted without loss of viability or the NPC's normal permeability barrier. Significantly, symmetric deletions caused mild reductions in Kap95-Kap60-mediated import rates, but virtually abolished Kap104 import. These results suggest the existence of multiple translocation pathways.

Status: Published Type: Journal Article PubMed ID: 15039779

Topics addressed in this paper

Number of different genes curated to this paper: 14

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Topics Genes linked to topics (#1 - 10 )
KAP104 KAP95 NSP1 NUP1 NUP100 NUP116 NUP145 NUP159 NUP2 NUP42
Additional Literature blue ball blue ball
Cellular Location blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 14 )
NUP49 NUP57 NUP60 SRP1
Additional Literature blue ball
Cellular Location blue ball
Genetic Interactions blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball

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