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Oki M, et al.  (2004) Barrier proteins remodel and modify chromatin to restrict silenced domains. Mol Cell Biol 24(5):1956-67

Abstract: Transcriptionally active and inactive domains are frequently found adjacent to one another in the eukaryotic nucleus. To better understand the underlying mechanisms by which domains maintain opposing transcription patterns, we performed a systematic genomewide screen for proteins that may block the spread of silencing in yeast. This analysis identified numerous proteins with efficient silencing blocking activities, and some of these have previously been shown to be involved in chromatin dynamics. We isolated subunits of Swi/Snf, mediator, and TFIID, as well as subunits of the Sas-I, SAGA, NuA3, NuA4, Spt10p, Rad6p, and Dot1p complexes, as barrier proteins. We demonstrate that histone acetylation and chromatin remodeling occurred at the barrier and correlated with a block to the spread of silencing. Our data suggest that multiple overlapping mechanisms were involved in delimiting silenced and active domains in vivo.

Status: Published Type: Journal Article PubMed ID: 14966276

Topics addressed in this paper

Number of different genes curated to this paper: 55

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ACA1 ADA2 AHC2 CLB1 COG2 CRF1 CUP2 DOT1 EFM2 EPL1
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Topics Genes linked to topics (#11 - 20 )
FLO8 FUB1 GAL11 GDS1 GIC1 HFI1 HMRA1 HSF1 ICY1 LEU3
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Topics Genes linked to topics (#21 - 30 )
LGE1 LYS5 MED2 MED6 MED8 MIC14 MND2 MRS6 NGG1 RGT1
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Topics Genes linked to topics (#31 - 40 )
ROX3 SAS2 SAS5 SFP1 SGF29 SGF73 SNF5 SNF6 SPT10 SPT15
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Topics Genes linked to topics (#41 - 50 )
SPT20 SPT21 SWA2 SWI4 SWI5 TAF12 TAF14 TAF3 TAF5 TAF6
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Topics Genes linked to topics (#51 - 55 )
TAF9 TFA2 YAP1802 YBL081W YNG1
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