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Holstege FC, et al.  (1998) Dissecting the regulatory circuitry of a eukaryotic genome. Cell 95(5):717-28

Abstract: Genome-wide expression analysis was used to identify genes whose expression depends on the functions of key components of the transcription initiation machinery in yeast. Components of the RNA polymerase II holoenzyme, the general transcription factor TFIID, and the SAGA chromatin modification complex were found to have roles in expression of distinct sets of genes. The results reveal an unanticipated level of regulation which is superimposed on that due to gene-specific transcription factors, a novel mechanism for coordinate regulation of specific sets of genes when cells encounter limiting nutrients, and evidence that the ultimate targets of signal transduction pathways can be identified within the initiation apparatus.

Status: Published Type: Journal Article PubMed ID: 9845373

Topics addressed in this paper

Number of different genes curated to this paper: 104

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AGA1 AGA2 ALD3 ARD1 BAR1 BCK1 BIM1 CAC2 CDC13 CDC5
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Topics Genes linked to topics (#11 - 20 )
CLB2 CTR9 CTT1 CYC7 DDC1 EXO1 FAR1 FAT3 FLO1 FLO11
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Topics Genes linked to topics (#21 - 30 )
FMP16 FUS2 GCN5 GPA1 GPH1 GRE1 HSM3 HSP12 HSP26 KAR4
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Topics Genes linked to topics (#31 - 40 )
KIN28 KIP2 LTE1 MCM3 MCM5 MCM6 MCM7 MDM1 MEC1 MED6
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Topics Genes linked to topics (#41 - 50 )
MFA1 MFA2 MIP1 MKK2 MSC1 MSH3 MSH6 NCA3 NQM1 PAC1
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Topics Genes linked to topics (#51 - 60 )
POT1 PUT4 RAD3 RAD5 RAD50 RAD9 RCK1 REV1 REV7 RFC1
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Topics Genes linked to topics (#61 - 70 )
RLF2 RPO21 RRM3 RRT13 RTA1 RTC2 RTN2 SCC2 SCP160 SIP18
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Topics Genes linked to topics (#71 - 80 )
SNF2 SOL4 SPC98 SPG4 SPI1 SPO1 SRB4 SRB5 SSN3 SST2
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Topics Genes linked to topics (#81 - 90 )
STE12 STE13 STE2 STE6 TAF1 TAF9 TFA1 TKL2 TOP3 TRX1
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Topics Genes linked to topics (#91 - 100 )
YBR116C YEL068C YEN1 YER084W YHR173C YIL054W YJR146W YKU80 YLR358C YNL140C
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Topics Genes linked to topics (#101 - 104 )
YNL143C YNL184C YNL194C YOR105W
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