SGD Paper 
Saudek V, et al. (1991) Solution structure of the basic region from the transcriptional activator GCN4. Biochemistry 30(5):1310-7
Abstract: The structure of the basic region (i.e., the region responsible for sequence-specific binding to DNA) of the transcriptional activator GCN4 was studied. Two peptide fragments containing either the basic region alone (residues 240-280) or the basic and the dimerization leucine zipper domains (220-280) were synthesized and investigated by nuclear magnetic resonance and circular dichroic spectroscopy. The basic region in the absence of DNA appears as a mobile flexible segment folded into a loose helix. The helical stability increases upon addition of trifluoroethanol and/or lowering of the temperature. Dimerization via the leucine zipper does not affect the three-dimensional structure of the basic region. Possible consequences for the binding to DNA are discussed.
| Status: Published | Type: Journal Article | PubMed ID: 1991112 |
Topics addressed in this paper
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| Topics | Genes linked to topics |
|---|---|
| GCN4 | |
| Primary Literature |  |
| Protein Sequence Features | |
| Protein/Nucleic Acid Structure | |
| Strains/Constructs | |
